Program in Human and Molecular Genetics

描述（由申请人提供）：本申请是对贝勒医学院分子和人类遗传学博士前培训计划的5年更新支持的请求。分子和人类遗传学系遵循三个原则，指导贝勒医学院追求创新生物医学：研究，教育和服务。该计划的使命是培养研究生的经典和现代遗传学的基础知识，并在应用这些原则，在生物医学创新。我们的目标是为学生提供严格和有条不紊的遗传学培训，同时强调研究和学术卓越，并帮助他们成为下一代生物医学科学家的领导者。目前有75名博士预科生在该计划，我们预计，12-16名新生将开始在该部门的研究生工作，每年。教师导师的数量是66，他们追求的研究项目，跨越广泛的利益，包括人类遗传学，基因组学，和人类疾病的分子基础，人类疾病的动物模型，微生物遗传学，发展，神经生物学，基因组稳定性和DNA复制。这些不同主题的共同主题是对遗传学的兴趣以及将研究结果应用于人类健康。进入该计划的学生在培训的第一年参加课程并进行实验室轮换。该课程为学生提供足够的背景来设计和分析基于遗传学的实验结果，旋转提供个性化的研究经验。学生们还参加了在基因组时代负责任地进行研究和人类遗传学伦理方面的专门培训。在第二年，学生参加资格考试，测试他们从课程和文献中整合知识的能力，并设计实验研究项目。然后，他们加入一个研究实验室，在其中一名教师导师的监督下开展研究项目。除了在实验工作的培训，学生学习如何分析他们的数据和写论文描述他们的工作，以及如何参与科学过程中的合议和建设性的方式。论文项目的高潮是论文的准备和答辩。在该计划中获得博士学位的平均时间为5.8年，平均出版物数量为每个学生5.5篇，平均第一作者论文2.2篇。目前，该补助金的培训职位数量为8个，我们要求将其增加到12个，以增加我们的受训人员的数量和多样性，以匹配不断增加的培训教师数量，并与遗传学培训项目的全国平均水平相匹配。 公共卫生相关性：该计划培养了新一代的学生在直接关系到人类健康，生理和疾病的研究课题。在这些学科中培养下一代遗传学家对于美国和世界各地医疗保健的持续发展至关重要。

DESCRIPTION (provided by applicant): This application is a request for a 5-year renewal of support for the Predoctoral Training Program in Molecular and Human Genetics at Baylor College of Medicine. The Department of Molecular and Human Genetics follows three principles that guide the pursuit of innovative biomedicine at Baylor College of Medicine: Research, Education and Service. The mission of this program is to train graduate students in the fundamentals of classical and modern genetics and in applying these principles to innovation in biological medicine. Our objectives are to provide students with rigorous and methodical training in genetics while emphasizing research and academic excellence, and to help them become leaders among the next generation of biomedical scientists. There are currently 75 predoctoral students in the program and we expect that 12-16 new students will initiate their graduate work in the department each year. The number of faculty mentors is 66 and they pursue research projects that span a wide range of interests, including human genetics, genomics, and the molecular basis of human diseases, animal models of human diseases, microbial genetics, development, neurobiology, genome stability, and DNA replication. The common theme of these varied topics is the interest in genetics and the application of the findings to human health. Students who enter the program spend the first year of their training taking courses and doing laboratory rotations. The courses provide students with sufficient background to design and analyze the results of genetic-based experiments and the rotations provide individualized research experiences. The students also participate in specialized training in the responsible conduct of research and in ethical aspects of human genetics in the genomic era. In the second year, students take a qualifying examination that tests their ability to integrate knowledge from courses and from the literature and to design an experimental research project. They then join a research laboratory in which they carry out a research project under the supervision of one of the faculty mentors. In addition to training in experimental work, students learn how to analyze their data and write papers describing their work, and how to participate in the scientific process in a collegial and constructive way. The thesis project culminates in the preparation and defense of a thesis dissertation. The average time to a PhD degree in the program is 5.8 years and the average number of publications is 5.5 per student, with 2.2 first-author papers on average. The current number of training positions on this grant is 8 and we are asking to increase it to 12 in order to increase the number and the diversity of our trainees, to match the increasing number of training faculty, and to match the national average among genetics training programs. PUBLIC HEALTH RELEVANCE: This program trains a new generation of students in research topics that are directly related to human health, physiology and disease. Training the next generation of geneticists in these subjects is essential for the continued development of health care in the US and throughout the world.