2011 International LAM Research Conference

描述（由申请人提供）：2011年LAM基金会淋巴血管平滑肌瘤病国际研究会议将重点讨论女性致命肺部疾病淋巴血管平滑肌瘤病（LAM）中平滑肌增生和囊性肺破坏的分子机制。这是第11届辛辛那提年度LAM会议，它已经从一个专门的家庭/患者会议发展成为LAM和结节性硬化症的最先进的科学会议。基础科学部分将重点研究LAM中平滑肌增殖的细胞和遗传基础，并将重点关注外源性生长因子、性激素、基因突变、淋巴管生成、细胞内信号机制和转录调控变化的作用。其他会议将探讨肺平滑肌浸润与肺实质囊性重构之间的联系，包括LAM细胞对金属蛋白酶和结缔组织基质的修饰。同时的临床会议将讨论LAM的困难管理问题，包括激素治疗、航空旅行、妊娠、肺移植和胸膜并发症。基础和临床科学轨道已经协调，允许所有参与者参加主题会议，并在会议之间自由交流。以患者为导向的研讨会将为预计参加的100名LAM患者和100名LAM家属讨论关键的临床问题，并将在基础和临床轨道主席的科学会议总结中达到高潮。会议的最后一天将举行科学圆桌讨论会，以审查会议的主要成果并规划未来的会议。每届会议将由该领域的一位专家主持，并将邀请演讲者以及从提交的摘要中选择的演讲者。一直有意识地努力吸引相关学科的知名研究人员，他们可以补充当前LAM研究人员的专业知识。由讨论领导推动的讨论将是所有会议的重要组成部分。优秀的青年研究人员将获得旅行补助，并有机会在平台和海报上展示他们的研究成果。本次会议的目的是为领先的专家提供一个论坛，讨论LAM的分子和细胞基础，回顾LAM的临床管理，介绍前沿研究，整合概念并确定创造性和创新性的研究方向。

DESCRIPTION (provided by applicant): The LAM Foundation 2011 Lymphangioleiomyomatosis International Research Conference will focus on the molecular mechanisms of smooth muscle proliferation and cystic lung destruction that occur in the fatal lung disease of women, Lymphangioleiomyomatosis (LAM). This is the eleventh annual Cincinnati LAM conference, which has evolved from a dedicated family/patient conference to a state of the art scientific meeting for LAM and tuberous sclerosis. The basic science sessions will highlight research on the cellular and genetic basis of smooth muscle proliferation in LAM, and will focus on the role of exogenous growth factors, sex hormones, genetic mutations, lymphangiogenesis, intracellular signaling mechanisms and changes in transcriptional regulation. Additional sessions will explore the link between smooth muscle infiltration of the lungs and the cystic remodeling of pulmonary parenchyma, including the elaboration of metalloproteinases and connective tissue matrix by LAM cells. Concurrent clinical sessions will address difficult management issues in LAM, including hormonal therapy, air travel, pregnancy, lung transplantation and pleural complications. The Basic and Clinical Science tracks have been coordinated to allow all participants to attend keynote sessions and to traffic freely between sessions. A patient-oriented seminar will address key clinical issues for one hundred LAM patients and 100 LAM family members who are expected to attend, and will culminate in a summary of scientific sessions by the Basic and Clinical Track Chairs. A scientific roundtable discussion is held on the last day of the conference to review the key outcomes of the conference and to plan future conferences. Each session will be chaired by an expert in the field and will have invited speakers as well as speakers chosen from the pool of submitted abstracts. There has been a conscious effort to attract established investigators from related disciplines who can complement the expertise of the current pool of LAM investigators. Discussion facilitated by a discussion leader will be an important component of all sessions. Outstanding junior investigators will be awarded travel grants and will be given the opportunity to present their research in platform and poster formats. The goal of this conference is to provide a forum for leading experts to discuss the molecular and cellular basis of LAM, review the clinical management of LAM, to present cutting edge research, to integrate concepts and to identify creative and innovative research directions.