RESBIO - the Technology Resource for Polymeric Biomaterials

描述(由申请人提供)：聚合物生物材料资源-RESBIO-将发现生物材料的新工程方法与细胞生物学和计算建模方面的最新研究相结合。通过这种独特的学科组合，RESBIO有助于对细胞-材料相互作用的定量(而不是定性)了解，从而加速发现具有特定医疗应用优化性能的聚合物生物材料。RESBIO的研究影响了生物材料科学、组织工程和再生医学领域，以及新型医疗植入物和药物输送系统的开发。在其第一个资助期内，RESBIO帮助开发了一种新的疝修补器(由FDA批准)和一种新的心血管支架(预计将在不久的将来进入临床试验)。在下一个资助期，RESBIO将通过以下方式将其研发核心研究计划扩展到新的方向：(I)从定性表征研究进展到定量表征研究；(Ii)从2D(平面)测试系统发展到3D模型系统，用于研究细胞与材料的相互作用；以及(Iii)纳入对细胞和组织作用的机械力的研究。 RESBIO将开发可通过服务、培训和广泛传播努力传播给其他实验室并纳入其研究活动的“一揽子技术”。核心教师来自五个机构：罗格斯大学、新泽西州立大学、宾夕法尼亚大学、克莱姆森大学、英国剑桥大学和国家标准与技术研究所。 七个拟议的合作项目、多样化的服务互动以及与主要国家研究计划的八个战略联盟将加强RESBIO在生物材料科学领域的影响力。

DESCRIPTION (provided by applicant): The Resource for Polymeric Biomaterials - RESBIO - integrates a new engineering approach to biomaterials discovery with state-of-the-art research in cell biology and computational modeling. Through this unique combination of disciplines, RESBIO contributes to a quantitative (rather than qualitative) understanding of cell-material interactions leading to the accelerated discovery of polymeric biomaterials with optimized properties for specific medical applications. RESBIO's research impacts the fields of biomaterials science, tissue engineering and regenerative medicine as well as the development of new medical implants and drug delivery systems. During its first funding period, RESBIO contributed to the development of a new hernia repair device (approved by FDA) and a new cardiovascular stent (expected to enter into clinical trials in the near future). In the next funding period, RESBIO will expand its R&D Core research program into new directions by (i) progressing from qualitative to quantitative characterization studies; (ii) advancing from 2D (flat) test systems to 3D model systems for the study of cell-material interactions; and (iii) incorporating the investigation of mechanical forces acting on cells and tissues. RESBIO will develop "technology packages" that can be disseminated to and incorporated into the research activities of other laboratories through service, training and broad dissemination efforts. Core faculty are drawn from five institutions: Rutgers, the State University of New Jersey, University of Pennsylvania, Clemson University, University of Cambridge, UK and the National Institute of Standards and Technology. Seven proposed collaborative projects, diverse service interactions, and eight strategic alignments with major national research programs will strengthen RESBIO's impact on the field of biomaterials science.