Midcareer investigator award in patient oriented research

描述(由申请者提供)：应聘者：招聘和留住富有成效的初级调查人员是学术医疗机构和整个研究界较为关键的优先事项之一。这一以患者为导向研究的职业生涯中期研究员奖的目的是为宾夕法尼亚大学生殖内分泌学家和流行病学家Kurt Barnhart MD，MSCE提供支持。巴恩哈特博士自1996年进入宾夕法尼亚大学任教以来，一直得到美国国立卫生研究院的持续支持，是一位成就卓著的临床研究人员。他也被公认为一位杰出的导师。应聘者的近期和长期职业目标集中在他作为一名以患者为导向的研究人员、教师和导师的愿望和意图上，继续发展和成熟。在这样做的过程中，他需要能够加强并将他的努力集中在开展以患者为导向的研究(POR)上，并为那些对妇女健康方面的POR感兴趣的人建立一条明确的培训和指导道路。这一奖励对于他实现这些目标至关重要，因为他可以通过减少临床和行政职责来保护50%的时间。他还将减少他资助的一些项目的努力，同时增加他目前指导的初级教师的努力。指导：巴恩哈特博士将通过NIH资助的T32生殖流行病学培训基金，将他的指导重点放在通过NIH资助的T32生殖流行病学培训基金注册的临床流行病学理学硕士(MSCE)的学者身上。该项目的候选人包括妇女健康、家庭医学和/或儿科学等子专业的研究员。其他学员将包括初级教员以及生殖内分泌学和不孕症研究员。他计划担任一些人的主要论文导师，另一些人的研究导师，并将过渡到T32培训补助金的PI。研究计划：本申请中提出的新科学将评估辅助生殖技术(ART)的短期和长期后果，ART是美国国立卫生研究院的优先研究领域。在一系列的三个具体目标中，他将调查抗逆转录病毒治疗与短期围产期发病率和儿童发育的关系。选择这三个目标是为了能够在合理的时间段内充分设计和进行研究，每个目标都有一个具体的假设，将导致重要的信息。为了解决这一重要的研究领域，人们提出了互补的、多样化的和复杂的研究方法，重点是克服不完美数据集的固有限制和非随机研究中的潜在偏差。SA#1将使用国家SART数据库来测试与冷冻胚胎移植相比，新鲜胚胎移植是否与增加不良结局有关。目的2是使用一项三臂队列研究，评估接受体外受精、超数排卵或无医疗帮助受孕的儿童的童年发育。SA#3将使用大型管理数据集将母亲和儿童联系起来，并在真实人口环境中评估自闭症谱系障碍。这些目标旨在提高PI的技能，加强多学科研究，并为指导提供最佳机会。最后，这些目标可能会提供证据，用于设计更大规模的试验，希望利用全国范围内越来越多的生殖流行病学家和POR研究人员，他们中的许多人将得到巴恩哈特博士的指导。

DESCRIPTION (provided by applicant): Candidate: The recruitment and retention of productive junior investigators is one of the more critical priorities of academic medical Institutions and the research community In general. The purpose of this Midcareer Investigator Award In Patient-Oriented Research is to provide support for Kurt Barnhart MD, MSCE, a reproductive endocrinologist and epidemiologist at the University of Pennsylvania. Dr. Barnhart is an accomplished clinical investigator with continuous NIH support since he has joined the faculty at Penn in 1996. He has also been recognized as an outstanding mentor. The candidate's immediate and long-term career goals center on his desire and intention to continue to evolve and mature as a patient-oriented researcher, teacher, and mentor. In doing so, he needs to be able to enhance and focus his efforts on conducting patient- oriented research (POR), and building a clear training and mentoring path for those interested in POR in women's health. This award will be essential to allow him to achieve these goals by protecting 50% of his time by reducing his clinical and administrative duties. He will also reduce effort on some of his funded projects while concomitantly increasing the effort of junior faculty he currently mentors. Mentoring: Dr. Barnhart will focus his mentoring on scholars enrolled in the Masters of Science in Clinical Epidemiology (MSCE) via the NIH supported T32 Reproductive Epidemiology training grant. Candidates for this program include fellows in sub-specialties in women's health, family medicine and/or pediatrics. Other mentees will include junior faculty, and fellows in Reproductive Endocrinology and Infertility. He plans to serve as primary thesis mentor for some, a research mentor for others, and will transition to become PI of the T32 training grant. Research Plan: New science proposed in this application will evaluate the short term and long term consequences of assisted reproductive technology (ART), a priory area of research for the NIH. In a series of three specific aims he will investigate the association of ART with short term perinatal morbidity and childhood development. These three aims were chosen for the ability to adequately design and conduct the study in a reasonable period of time, each with a specific hypothesis that would lead to important information. Complementary, diverse, and sophisticated research methods have been proposed to address this important research area, with focus on overcoming inherent limitations in imperfect datasets and potential bias in nonrandomized studies. SA#1 will use the national SART database to test if a fresh embryo transfer is associated with increased adverse outcome compared to frozen embryo transfer. Aim #2 is use a three arm cohort study assessing childhood development in children conceived with IVF, superovulation or without medical assistance. SA #3 will use a large administrative dataset to link mothers and children and assess for autistic spectrum disorder in true population setting. These aims are designed to advance the skills of the PI, enhance multidisciplinary research and provide optimal opportunity for mentorship. Finally these aims will likely provide evidence to be used to design larger trials, hopefully using the growing cadre of reproductive epidemiologists and POR researchers in women's health nationwide, many of whom will have been mentored by Dr Barnhart.