FOSTERING PATIENT ORIENTED RESEARCH IN PEDIATRIC NUTRITION

描述(由申请人提供)： 此次续展申请以患者为中心的研究(POR)职业中期研究人员奖(K24)，旨在为致力于人类营养方面卓越研究的研究人员提供支持，并指导未来的儿科营养领导者。申请的目的是使候选人能够继续她在POR方面的努力，并培养她指导临床研究人员和其他儿科营养学实习生的能力。这位候选人在进行POR方面有着出色的记录，POR得到了联邦和非联邦来源的资助。在她最初获得K24奖的头四年里，她与人合著了47篇论文和30篇摘要，她指导了20名博士后和博士后实习生，其中包括4名内科研究员和3名博士后研究员，他们都进行了与儿科营养直接相关的研究项目。候选人的主要研究重点是微量营养素营养，特别是在婴幼儿中。她目前正在进行几项与发展中国家锌的动态平衡和生物利用度有关的试验。第二个感兴趣的合作研究领域是儿童肥胖症的预防和治疗。申请中描述了三个由POR资助的项目：一项为4个发展中国家的婴幼儿提供肉类作为补充食品的随机分组试验；一项比较美国母乳喂养婴儿三种不同补充喂养方案的代谢研究；以及一项初步研究，旨在研究基于办公室的电子系统的可行性，以增强提供者对儿童肥胖和心血管疾病风险的评估。具体的指导目标是1)招募优秀的实习生，特别是医生，进入儿科营养领域，以增加该领域的医生领导人数；2)通过更新的、合作的培训轨道，为儿科营养博士后研究员实施有组织的、严格的培训计划。这一奖项将大大有助于候选人的职业目标，使她能够放弃一些临床和管理职责，并利用职业发展机会，这两者都将增强她指导下一代临床研究人员的能力。 相关性：该项目涉及儿科公共卫生重要性的两个主要领域的人类营养研究：微量营养素缺乏和肥胖。该奖项寻求对在儿科营养领域进行以患者为导向的研究和指导临床研究人员的长期记录的申请者的支持。

DESCRIPTION (provided by applicant): This renewal application for a Mid-career Investigator Award (K24) in Patient Oriented Research (POR) seeks support for an investigator who is committed to excellent research in human nutrition, and to mentoring future leaders in Pediatric Nutrition. The objective of the application is to enable the candidate to continue her efforts in POR, and to foster her ability to mentor clinical investigators and other trainees in Pediatric Nutrition. The candidate has an excellent record of conducting POR, which has been funded by both federal and non-federal sources. During the first four years of her original K24 award, she has coauthored 47 publications and 30 abstracts, and she has mentored 20 pre- and post-doctoral trainees, including 4 physician fellows, and 3 post-doctoral fellows, all of whom conducted research projects directly relevant to Pediatric Nutrition. The candidate's primary research focus is micronutrient nutrition, especially in infants and young children. She is currently conducting several trials related to zinc (Zn) homeostasis and bioavailability in developing countries. A second area of interest and collaborative research is pediatric obesity prevention and treatment. Three funded POR projects are described in the application: a cluster randomized trial providing meat as a complementary food to infants and toddlers in 4 developing countries; a metabolic study comparing 3 different complementary feeding regimens in U.S. breastfed infants; and a pilot study examining the feasibility of an office-based electronic system to enhance providers' assessment of obesity and cardiovascular disease risk in children. The specific mentoring aims are 1) to recruit outstanding trainees, especially physicians, to the field of Pediatric Nutrition so as to increase the number of physician leaders in this area; and 2) to implement a structured, rigorous training program for post-doctoral fellows in Pediatric Nutrition through an updated, collaborative training track. This award will substantially contribute to the candidate's career goals by enabling her to relinquish some clinical and administrative duties and to take advantage of career enhancement opportunities, both of which will enhance her ability to mentor the next generation of clinical investigators. Relevance: This project addresses human nutrition research in two major areas of public health importance in Pediatrics: micronutrient deficiencies and obesity. The award seeks support for an applicant who has a long track record of conducting patient oriented research and of mentoring clinical investigators in the area of Pediatric Nutrition.