Short-Term Training to Increase the Diversity Pipeline in Heart/Lung/Blood Resear

描述（由申请人提供）：亚利桑那大学（UA）医学院多样化学生医学研究计划（DSMRP）将介绍，培训和培养医学和本科生[包括代表性不足的少数民族（URM）]在健康相关的基础/临床生物医学研究（强调心血管、肺、血液）;并鼓励随后的密集/广泛的研究经验，以保留和加强多样化的学生研究人员管道。我们将在现有医学生和弱势高中生项目的基础设施、高水平的学生和教师导师参与、团队精神以及出色的实习生生产力的基础上，弥合入学和退出学生的不连续多样性管道，因为他们在培训中取得进展并为专业/学术事业而奋斗。全日制暑假实验室/临床研究将被纳入集中在暑期研究所（SIMI）的医学无知（CMI）创新课程，并通过全年与受训者相关的丰富活动持续进行。这些包括专题研讨会，临床相关性，先进的课外研究在研究荣誉区别跟踪，介绍分子医学实验室实习，一个新的渐进的“翻译翻译”面对面/在线课程交织已知和未知的从板凳到床边社区，研究方法/通信/领导/负责任的行为研讨会，客座教授，和职业咨询。CMI培养态度和提问技能，以认识和处理医学无知的巨大变化世界[“我们知道我们不知道（研究），不知道我们不知道（发现），认为我们知道但不知道（错误）"]。一个独特的虚拟临床研究中心，包括医疗设备，是培训和国家/国际网络的中心。围绕扩大UA专业卓越中心和部门组织，并由项目总监，基础临床科学顾问和学院选举的医学生研究委员会监督，研究包括跨领域主题和体内，体外，原位，计算机模拟和心血管（CV）系统及其疾病的建模方法（心肌收缩力、肥大、发育;基因组学/蛋白质组学、成像、生物材料、修复学;内皮生物学、微循环生理学、淋巴学、生物工程）;以及癌症、神经科学、生物信息学和学生感兴趣的其他主题的交叉研究。基于我们的~30年的跟踪记录和访问不同/弱势群体反映在729医学生和474高中学生培训到目前为止，我们预计，DSMRP将培养许多不同的科学医生贡献者的研究企业和不断增长的骨干医学科学家领导人，以激励医疗保健专业人员和翻译研究人员的稀缺多样性管道。详细的S/T和L/T形成/总结计划和参与者评估，包括数据库登记，个人发展计划和职业组合，将记录有效性并促进网络。 公共卫生相关性：该提案将制定和实施一个示范计划，以招募，培训和指导大量不同/弱势（包括URM）的本科生和医学生，主要针对心脏，肺，血液疾病的生物医学研究。我们将开发一个职业管道，以促进保留和职业发展，从而有助于创建未来的多元化临床研究团队和推进医学发现从板凳到床边到社区的翻译NIH路线图目标。

DESCRIPTION (provided by applicant): The University of Arizona (UA) College of Medicine Diverse Student Medical Research Program (DSMRP) will introduce, train, and nurture inquiring medical and undergraduate students [including under-represented minorities (URM)] in health-related basic/clinical biomedical research (emphasizing cardiovascular, pulmonary, blood); and encourage subsequent intensive/extensive research experiences to retain and strengthen the diverse student researcher pipeline. We will build on the infrastructure, high level of student and faculty mentor participation, esprit-de-corps, and outstanding trainee productivity of our current medical student and disadvantaged high school student programs to bridge the discontinuous diversity pipeline of entering and exiting students as they advance in training and strive for professional/academic careers. Full-time summer-vacation laboratory/clinical investigations will be integrated into an innovative Curriculum on Medical Ignorance (CMI) concentrated in a Summer Institute (SIMI) and sustained through year-round trainee-related enrichment activities. These include topical workshops, clinical correlations, advanced extracurricular research in a Research Honors Distinction Track, Introduction to Molecular Medicine laboratory practicum, a new progressive "Translating Translation" face-to-face/online curriculum interweaving the known and unknown from bench to bedside to community, research methodology/communications/leadership/responsible conduct seminars, visiting professors, and career advising. CMI fosters attitudes and questioning skills to recognize and deal with the vast shifting world of medical ignorance ["what we know we don't know (research), don't know we don't know(discovery), and think we know but don't (error)"]. A unique Virtual Clinical Research Center with Questionarium forms a centerpiece for training and national/international networking. Organized around expanding UA Specialized Centers of Excellence and departments and overseen by Program Director, Basic-Clinical Science Advisors, and faculty-elected Medical Student Research Committee, research encompasses cross-cutting themes and in vivo, in vitro, in situ, in silico, and modeling approaches to the cardiovascular (CV) system and its disorders (cardiac contractility, hypertrophy, development; genomics/proteomics, imaging, biomaterials, prosthetics; endothelial biology, microcirculatory physiology, lymphology, bioengineering); and interdigitating research in cancer, neurosciences, bioinformatics, and other topics of interest to students. Based on our ~30-year track record and access to diverse/disadvantaged populations reflected in 729 medical students and 474 high school students trained to date, we anticipate that DSMRP will cultivate many diverse scientific physician contributors to the research enterprise and a growing cadre of medical scientist leaders to energize the scanty diversity pipeline of healthcare professionals and translational researchers. Detailed S/T and L/T formative/summative program and participant evaluation including database registry, individual development plans, and career portfolios, will document effectiveness and promote networking. PUBLIC HEALTH RELEVANCE: This proposal will develop and implement a model program to recruit, train and mentor a large number of diverse/disadvantaged (including URM) undergraduates and medical students in biomedical research predominantly targeting heart, lung, blood disorders. We will develop a career pipeline to promote retention and career progression, thereby contributing to the NIH Roadmap goals of creating the diverse clinical research teams of the future and advancing translation of medical discoveries from bench to bedside to community.