Effects of Marijuana on Driving: a Standardized Assessment

描述（由申请人提供）：大麻中毒时驾驶是一个严重的问题。几乎一半的12年级学生尝试过大麻，四分之一的学生在大麻的影响下开车。1目前还没有简单的标准化评估，可以通过最低限度的培训进行管理和分析，以测试大麻中毒造成的损害。这项研究将评估两个任务的敏感性，这两个任务可以用最少的训练和时间来管理，与大麻（安慰剂，200 mcg/kg和300 mcg/kg）的剂量依赖性效应的简短模拟驱动器相比。将招募50名健康的偶尔吸食大麻的人参加三次访问，每次访问期间，他们将完成换道测试、注意力评估和多个时间间隔的模拟驾驶。据推测，所有的任务将显示剂量依赖性损害后立即使用大麻的性能，并随着时间的推移，损害将减少。进一步假设，车道变换测试和注意力评估，提供快速和简单的汇总统计损伤，将适用于大麻中毒的工作场所评估。 公共卫生相关性：在大麻中毒的情况下开车是一个严重的公共卫生问题，因为几乎一半的12年级学生尝试过大麻，四分之一的学生在大麻的影响下开车。这项研究将评估车道变换任务和注意力评估的敏感性，与模拟驾驶相比，在多个时间点和剂量下检测大麻损伤的能力。识别快速，可靠，可以进行最少的培训评估将有助于检测由于大麻导致的驾驶障碍，并可能降低其流行率，从而挽救生命。

DESCRIPTION (provided by applicant): Driving while intoxicated by marijuana is a serious concern. Almost half of 12th graders have tried marijuana and 1 in 4 have driven under its influence.1 Currently there is no brief standardized assessment that can be administered and analyzed with minimal training to test for impairment from marijuana intoxication. This study will evaluate the sensitivity of two tasks that can be administered with minimal training and time in comparison with an abbreviated simulated drive on the dose-dependent effects of marijuana (placebo, 200 mcg/kg and 300 mcg/kg). Fifty healthy, occasional users of marijuana will be recruited to participate in three visits each during which they will complete the Lane Change Test, The Attention Assessment and a simulated drive at multiple time intervals. It is hypothesized that all tasks will show a dose dependent impairment in performance immediately following marijuana use and that impairment will diminish over time. It is further hypothesized that the Lane Change Test and The Attention Assessment, which provide quick and easy summary statistics of impairment, will be suitable for use in workplace assessment of marijuana intoxication. PUBLIC HEALTH RELEVANCE: Driving while intoxicated by marijuana is a serious public health concern as almost half of 12th graders have tried marijuana and 1 in 4 have driven under its influence. This study will evaluate the sensitivity of the Lane Change Task and The Attention Assessment in comparison with simulated driving on the ability to detect marijuana impairment at multiple time points and doses. Identification of fast, reliable, assessments that can be conducted with minimal training will aid in the detection of driving impairment due to marijuana and potentially decrease its prevalence, thereby saving lives.