Research Career Development in Child Health

描述（由申请人提供）：我们的儿童健康研究职业发展奖励计划的目标是推进儿童健康研究，并为对儿童疾病感兴趣的初级儿科研究者激发新的研究倡议和职业发展。我们的项目支持最近完成亚专业培训的儿科医生的研究职业发展，他们正在从事与儿童健康相关的基础、转化和/或临床研究。它包括教学和研究部分，以提供关于许多儿童疾病的发病机制和演变的培训，包括与早产有关的肺部疾病、囊性纤维化、哮喘、肺炎、败血症、癌症、凝血障碍、骨髓移植、糖尿病、肥胖和心血管疾病、由病毒和细菌病原体引起的疾病，以及困扰儿科人群的其他疾病。这些疾病背后的过程包括急性和慢性炎症、先天和特异性免疫、癌细胞生物学、干细胞生物学和氧化应激。解决这些问题的技术和方法包括基因组学、蛋白质组学、代谢组学、生物成像、细胞和分子生物学、生物信息学、包括突变小鼠技术在内的体内方法和流行病学。教学阶段包括免疫生物学、流行病学和生物统计学等研究生水平课程的培训，以及与学者兴趣相关的其他主题，包括基因组学和蛋白质组学、生物成像、科学写作和口头报告等生物技术方面的培训。一个关键的组成部分是导师和共同导师在实验室的指导研究经验。这些学者将作为他们所选择的研究项目的正式成员参加，并根据项目的需要与项目的其他成员和共同导师进行互动。随着时间的推移，他们自己的研究项目和方向将从这种培育环境中成长起来。44位教师导师，27位来自儿科10个部门，领导着杰出的，国家认可的研究项目，他们与CWRU在癌症，免疫生物学，感染和代谢综合征等丰富社区的许多同事进行互动。我们的目标是：1)在多学科合作研究方面提供优秀的培训，使我们的学者为成功的职业生涯做好准备，成为追求儿童疾病重要问题的独立研究者；2)培养具有未来生物医学研究所需的必要能力和专业知识广度的新研究者；3)提供优秀的导师和共同导师。4)在科学队伍中招募和留住训练有素的新研究人员，并确保该队伍中人员的多样性得到充分体现，5)提供合格的内科科学家的持续流动，他们能够从事调查疾病过程的基础研究，并在基础和临床领域之间自由地转化研究结果。

DESCRIPTION (provided by applicant): The objectives of our Child Health Research Career Development Award Program are to advance research in child health and to stimulate novel research initiatives and career development for junior pediatric investigators interested in diseases of childhood. Our Program supports research career development of pediatricians who have recently completed subspecialty training and who are pursuing careers in basic, translational and/or clinical research relevant to child health. It includes didactic and research components to provide training in the pathogenesis and evolution of numerous childhood diseases, including lung disease associated with prematurity, cystic fibrosis, asthma, pneumonia, sepsis, cancer, coagulation disorders, bone marrow transplantation, diabetes, obesity and cardiovascular disease, diseases caused by viral and bacterial pathogens, and other illnesses that afflict the pediatric population. The processes underlying these diseases include acute and chronic inflammation, innate and specific immunity, cancer cell biology, stem cell biology, and oxidative stress. The technologies and methodologies to address these questions include genomics, proteomics, metabolomics, bioimaging, cell and molecular biology, bioinformatics, in vivo approaches including mutant mouse technologies, and epidemiology. A didactic phase includes training in graduate- level courses in immunobiology, epidemiology and biostatistics and other topics relevant to a scholar's interests, training in biotechnologies including genomics and proteomics, bioimaging, scientific writing and oral presentation. A critical component is the mentored research experience in the laboratories of mentors and co-mentors. The scholars will participate as full members of their selected research program, interacting with the other members of the program and with co-mentors as required for their projects. Over time, their own research programs and directions will grow from this nurturing environment. The 44 faculty mentors, 27 from 10 divisions within the Department of Pediatrics, lead outstanding, nationally recognized research programs, and they interact with many colleagues in the rich communities in cancer, immunobiology, infection, and metabolic syndrome at CWRU. The goals are 1) to provide outstanding training in collaborative multi-disciplinary research to prepare our Scholars for successful careers as independent investigators pursuing important questions in childhood diseases, 2) to develop new investigators with the necessary competencies and breadth of expertise needed for the future of biomedical research, 3) to provide excellent mentor- and co-mentorship, 4) to recruit and retain our well-trained new investigators in the scientific workforce and to ensure adequate representation of diversity among people in that workforce, and 5) to provide a continuing flow of qualified physician scientists well able to pursue basic research investigating disease processes and to translate findings freely between the basic and clinical spheres.