Field Validation of a Personal Sensor for Ultrafine PM in Asthmatic Children

描述（由申请人提供）：交通相关空气污染（TRAP）对人类健康影响的流行病学研究经常受到使用替代、环境或模拟暴露的限制。在易感亚人群中，特别是儿童中，个人监测的必要性是显而易见的，因为他们除了在家之外，还在学校和车辆中度过了大量时间。此外，儿童可能有高水平的身体活动，并且离颗粒源很近，导致接触水平高于固定采样点记录的水平。为了解决目前表征暴露的局限性，一种能够以高时空分辨率测量超细颗粒（UFP）暴露的个人和可穿戴传感器已经开发并在实验室环境中进行了验证。尽管这种个人传感器被开发得足够小、坚固、简单，可以在流行病学研究中广泛使用，但它还没有在实验室外得到验证或在现场使用。因此，本应用程序的目的是在现场验证这种高度创新的传感器，并在正在进行的学校和社区TRAP暴露流行病学研究中对传感器进行现场测试。这项研究将受益于工程师和流行病学家的合作，以生产能够用于流行病学研究的UFP个人传感器。为了实现研究目标，所开发的传感器将在现场与现有的、非个人的、金标准的仪器进行验证。在对传感器进行验证之后，将在当前正在进行的流行病学研究辛辛那提反怠速运动（CAIC）研究的背景下对个人传感器进行现场测试。参加CAIC的儿童就读于四所参与的辛辛那提公立学校之一，他们从附近的道路或校车上接触到不同程度的TRAP。此外，CAIC参与者患有哮喘，并已完成初步健康评估。目前，cac研究通过使用学校和社区环境空气监测来评估对TRAP的暴露情况。因此，CAIC研究非常适合评估个人监测的益处，并确定开发的传感器在市中心哮喘儿童人群中的可接受性和可用性。现场试验的结果将提供反馈，以便修改传感器，为流行病学研究的广泛使用做准备。

DESCRIPTION (provided by applicant): Epidemiologic studies of the impact of traffic-related air pollution (TRAP) on human health are frequently limited by the use of surrogate, ambient, or modeled exposure. The need for personal monitoring is evident in susceptible subpopulations, particularly children, who spend significant time at schools and in vehicles, in addition to their homes. Further, children may have high levels of physical activity and be in close proximity to particulate sources that result in higher levels of exposure than those recorded at stationary sampling sites. In order to address current limitations in characterizing exposure, a personal and wearable sensor capable of measuring, with high spatiotemporal resolution, exposure to ultrafine particles (UFP) has been developed and validated in laboratory settings. Though the personal sensor was developed to be sufficiently small, rugged, and straightforward to allow its widespread use in epidemiologic studies, it has not been validated outside the laboratory or utilized in the field. Therefore, the objectives of this application are to validate this highly innovative sensor in the field and conduct a field test of the sensor in an ongoing epidemiologic study of TRAP exposure at schools and communities. This study will benefit from the collaboration of engineers and epidemiologists to produce a personal sensor for UFP capable of being utilized in epidemiologic studies. In order to achieve the study objectives, the developed sensor will be validated in the field against current, non- personal, gold-standard instruments. Following the validation of the sensor, a field test of the personal sensor will be conducted within the context of a currently ongoing epidemiologic study, the Cincinnati Anti-Idling Campaign (CAIC) study. Children enrolled in the CAIC attend one of four participating Cincinnati Public Schools with varying exposure to TRAP from nearby roads or school buses. In addition, CAIC participants are asthmatic and have completed an initial health assessment. Exposure to TRAP is currently assessed in the CAIC study through the use of school and community ambient air monitoring. Thus, the CAIC study is ideal to assess the benefit of personal monitoring and to determine the acceptability and usability of the developed sensor in a population of inner-city asthmatic children. The results of the field test will provide feedback in order to modify the sensor in preparation for wide-spread use in epidemiologic studies. PUBLIC HEALTH RELEVANCE: Epidemiologic studies of the impact of traffic-related air pollution (TRAP) on human health are frequently limited by the use of surrogate, ambient, or modeled exposure. In order to address current limitations in characterizing exposure, a personal and wearable sensor capable of measuring, with high spatiotemporal resolution, exposure to ultrafine particles (UFP) has been developed and validated in laboratory settings. The objectives of this application are to validate this highly innovative sensor in the field and conduct a field test of the sensor in an ongoing epidemiologic study of TRAP exposure at schools and communities.