CH/BIDMC/Harvard Medical School Neurology Resident Research Education Program

描述（由申请人提供）：该奖项的目的是创造一个机会，为选定的居民在贝丝以色列女执事医疗中心（BIDMC）和波士顿儿童医院（CHB）的神经病学住院医师培训计划，参加9至24个月的密集，指导，研究教育经验，在住院医师的第三年和随后的奖学金年。这项培训的目的是准备参与居民成功竞争的独立指导研究奖，并将促进从居民/研究员临床科学家的过渡。每位参与者将与37位导师中的一位合作，这些导师是从CHB，BIDMC和哈佛医学院（HMS）的院系招募的。他们都有积极的NIH资金和培训临床科学家的历史。拟议的导师涵盖临床和基础神经科学的所有主要领域，包括来自CHB的20名研究人员，来自BIDMC的16名研究人员和来自HMS的一名研究人员（Michael Greenberg博士，CHB神经生物学项目的前负责人，现任HMS神经生物学主席）。其中17名研究人员从事临床/转化神经科学研究，12名进行基础神经科学研究，8名同时参与基础和临床/转化研究。导师不仅来自神经病学/神经生物学部门，还来自CHB神经病理学部门、CHB神经放射学部门、CHB神经外科部门、BIDMC神经病理学部门和BIDMC麻醉部门的疼痛研究项目。选定的居民参与者将学习最先进的实验室技能，并将获得进行负责任的研究所需的关键专业知识。收集和分析的数据将用于出版物以及未来的NIH提案。该计划将由一个指导委员会管理，该委员会由PD/PI，部门主席和参与居住计划的居住主任组成。该委员会将共同努力招聘和挑选受训人员，监测他们的进展情况，并评估培训经验的有效性。 公共卫生相关性：影响神经系统的疾病仍然是医学研究的一大挑战。发现这些疾病的原因，从而导致早期诊断和更好的治疗，需要越来越多地依赖于概念复杂性和复杂方法的研究。目前的R25提案旨在培养能够将住院医师期间获得的临床专业知识与完善的重点调查研究计划结合起来的联合收割机研究人员。神经内科住院医师敏锐地意识到需要解决的问题，并特别有动力和精力去解决这些问题。CHB/BIDMC住院医师计划将成人和儿童神经病学结合在一个基础和临床神经科学非常深入的环境中。为R25选择的导师包括领先的NIH资助的基础细胞和分子神经科学家，以及积极从事临床和基础神经科学的成功医生科学家，并有经验，并渴望培养医生科学家。拟议计划的主要重点将是为独立和竞争性研究做好准备。

DESCRIPTION (provided by applicant): The aim of this award is to create an opportunity for selected residents in the neurology residency training programs of the Beth Israel Deaconess Medical Center (BIDMC) and the Children's Hospital Boston (CHB) to participate for 9 to 24 months in an intensive, mentored, research educational experience during the third year of residency and subsequent fellowship years. This training will be designed to prepare participating residents for successful competition for independent mentored research awards, and will facilitate the transition from resident/fellow to clinician-scientist. Each participant will work with one of 37 mentors, who have been recruited from the faculties of CHB, BIDMC, and Harvard Medical School (HMS). All have active NIH funding and a history of training clinician-scientists. The proposed mentors cover all major areas of the clinical and basic neurosciences, and include 20 investigators from CHB, 16 investigators from BIDMC, and one investigator from HMS (Dr. Michael Greenberg, former leader of the Neurobiology Program at CHB, now Chair of Neurobiology at HMS). Seventeen of these investigators are engaged in clinical/translational neuroscience research, twelve conduct basic neuroscience research, and eight are involved in both basic and clinical/translational research. Mentors have been drawn not only from the Departments of Neurology/Neurobiology, but also from the CHB Division of Neuropathology, the CHB Division of Neuroradiology, the CHB Department of Neurosurgery, the BIDMC Division of Neuropathology, and the Pain Research Program of the BIDMC Department of Anesthesia. Selected resident participants will learn state-of- the-art laboratory skills and will acquire the critical expertise necessary for the conduct of responsible research. Data collected and analyzed will serve for publications as well as for future NIH proposals. The program will be governed by a Steering Committee consisting of the PD/PIs, the Department Chairs, and the Residency Directors of the participating residency programs. This Committee will work together to recruit and select trainees, to monitor their progress, and to evaluate the effectiveness of the training experience. PUBLIC HEALTH RELEVANCE: Illnesses affecting the nervous system remain a great challenge to medical research. The discovery of the causes of these illnesses, leading to earlier diagnosis and better treatments, requires research that relies increasingly on conceptual complexities and sophisticated methodologies. The present R25 proposal is aimed at developing researchers that can combine the clinical expertise obtained during residency with a well developed and focused investigative research program. Neurology residents are keenly aware of the problems that need to be solved and are especially motivated and energized to solve them. The CHB/BIDMC residency program combines both adult and child neurology within an environment that has great depth in basic and clinical neuroscience. Mentors chosen for the R25 include leading NIH funded basic cellular and molecular neuroscientists, as well as successful physician scientists actively engaged in clinical and basic neuroscience and experienced in, and eager to train physician scientists. The main focus of the proposed program will be to prepare physicians for independent and competitive research.