Training Programs in Cancer Pharmacology

描述（由申请人提供）：本申请建议开发多学科癌症药理学培训计划（CPTP），为博士前和博士后学员提供凯斯西储大学目前不存在的培训机会。在不久的将来，癌症治疗和预防的重大进展将来自多学科方法，以阐明肿瘤发生和发展的基础过程，并开发和实施新的治疗和预防癌症的策略。该计划的目标是教授癌症药理学的基础知识，并培养学生参与多学科相互作用的癌症药理学方法。因此，该计划将有助于填补个人谁可以在学科之间自由移动，并与来自不同领域的科学家进行有效的互动，以开发下一代化疗药物的当前赤字。这些目标将通过所提供的课程和将从教师提供的多学科研究经验来实现。项目主任Noa Noy和咨询委员会将在癌症药理学领域的多学科环境中为博士前和博士后科学家的招聘和培训提供持续的领导。35名具有不同互补专业知识的教师导师将被分为四个子项目：癌症生物学，癌症药物设计和递送，成像和癌症系统生物学。每个学员将有来自其中两个项目的研究导师。这个项目的导师们作为癌症研究人员有着非常出色的成就记录。他们是76个NIH赠款的主要研究者或项目负责人。除了培训赠款外，29名导师还获得了NIH资助的研究赠款（主要通过NCI）。在过去10年中，导师们培训了210名博士前学生和192名博士后研究员;目前，他们的实验室有126名博士前和111名博士后学员。 公共卫生相关性：本申请建议开发一个多学科的癌症药理学培训计划（CPTP），为博士前和博士后学员提供凯斯西储大学目前不存在的培训机会。该计划的目标是教授癌症药理学的基础知识，并培养学生参与多学科相互作用的癌症药理学方法。因此，该计划将有助于填补个人谁可以在学科之间自由移动，并与来自不同领域的科学家进行有效的互动，以开发下一代化疗药物的当前赤字。这些目标将通过课程和多学科的研究经验来实现。项目主任Noa Noy和咨询委员会将在癌症药理学领域的多学科环境中为博士前和博士后科学家的招聘和培训提供持续的领导。36名具有不同互补专业知识的教师导师将被分为四个子项目：癌症生物学，癌症药物设计和递送，成像和癌症系统生物学。每个学员将有来自其中两个项目的研究导师。

DESCRIPTION (provided by applicant): This application proposes to develop a multidisciplinary Cancer Pharmacology Training Program (CPTP) to provide predoctoral and postdoctoral trainees with a training opportunity that does not currently exist at Case Western Reserve University. Major advances in the treatment and prevention of cancer in the near future will emerge from multidisciplinary approaches to elucidating the processes that underlie tumor initiation and progression and to developing and implementing novel strategies for therapy and prevention of cancer. The goals of the program are to teach the fundamentals of cancer pharmacology, and to train students in approaches to cancer pharmacology that involve multidisciplinary interactions. The program will thus help fill the current deficit of individuals who can move freely between disciplines and productively interact with scientists from various areas to develop the next generation of chemotherapeutic agents. These goals will be accomplished through the courses that are offered and the multidisciplinary research experiences that will be available from the faculty. The program director, Noa Noy, and the advisory committee will provide the sustained leadership required for the recruitment and training of both predoctoral and postdoctoral scientists in the multidisciplinary environment of the field of cancer pharmacology. The 35 faculty mentors with diverse complementary expertise will be grouped into four sub-programs: Cancer biology, Cancer Drug Design and Delivery, Imaging, and Cancer Systems biology. Each trainees will have research mentors from two of these programs. The mentors on this proposed program have a very strong record of accomplishment as cancer researchers. They are Principal Investigators or Project Leaders on 76 NIH grants. Apart from training grants, 29 of the mentors have NIH-funded (primarily through NCI) research grants. Over the past 10-years, the mentors have trained 210 predoctoral students and 192 postdoctoral fellows; they currently have 126 predoctoral and 111 postdoctoral trainees in their laboratories. PUBLIC HEALTH RELEVANCE: This application proposes to develop a multidisciplinary Cancer Pharmacology Training Program (CPTP) to provide predoctoral and postdoctoral trainees with a training opportunity that does not currently exist at Case Western Reserve University. The goals of the program are to teach the fundamentals of cancer pharmacology, and to train students in approaches to cancer pharmacology that involve multidisciplinary interactions. The program will thus help fill the current deficit of individuals who can move freely between disciplines and productively interact with scientists from various areas to develop the next generation of chemotherapeutic agents. These goals will be accomplished through coursework and through multidisciplinary research experiences. The program director, Noa Noy, and the advisory committee will provide the sustained leadership required for the recruitment and training of both predoctoral and postdoctoral scientists in the multidisciplinary environment of the field of cancer pharmacology. 36 faculty mentors with diverse complementary expertise will be grouped into four sub-programs: Cancer biology, Cancer Drug Design and Delivery, Imaging, and Cancer Systems biology. Each trainees will have research mentors from two of these programs.