Research and Mentoring on Energetic Factors and Cancer: Established Investigator

描述(申请人提供)：K05奖项将为Leslie Bernstein博士提供40%的保护时间(20%的研究和20%的指导)，以与被辅导者进行研究，研究身体活动与身体尺寸(独立使用身高、体重、腰围和臀围，以及各种比率指标，如体重指数、腰臀比和腰围高度比)与乳腺癌、子宫内膜癌、卵巢癌、肺、结肠、胰腺癌、膀胱癌、直肠癌和甲状腺癌、非霍奇金淋巴瘤和黑色素瘤的风险之间的关系。伯恩斯坦博士长期成功地指导南加州大学(USC)的学生(本科、硕士、博士)和博士后研究员、临床研究员和初级教员。在希望之城，伯恩斯坦博士将专注于指导人口科学、医学肿瘤学和外科肿瘤学系的初级教员和博士后研究员，以鼓励他们追求癌症预防和控制方面的问题。她将继续指导南加州大学的博士和硕士学生，以及克莱蒙特研究生院新成立的社区和全球卫生学院的公共卫生硕士和博士生。研究目标是鼓励受试者关注癌症发展或预后的风险因素，这些因素适合于生活方式干预，并考虑如何在人群中实施这些干预措施。具体的指导目标是促进被辅导者的职业发展；提供癌症病因和预防方面的成长机会；促进对组织文化的理解；指导研究网络的发展，以促进职业目标；并就如何确定优先顺序和提高效率提出建议。受训者将在伯恩斯坦博士的精心指导下，利用加州教师研究队列(CA077398，6/1/04-5/31/09，Bernstein，PI)对自1995年以来发生癌症的133,479名女性进行跟踪调查，继续进行新的、没有资金支持的领域的研究。到目前为止，队列参与者已经完成了4份问卷，具有独特的特征，包括吸烟者很少(5%)，获得医疗保健的机会，激素治疗的高使用率，不同的社会经济地位和居住背景，以及独特的生育史。被辅导者将与伯恩斯坦博士合作，就体力活动和体型测量之间的相互作用提出问题，以确定乳腺癌的总体风险和预后，并按亚型确定乳腺癌的风险和预后，如果有足够的数字，则确定一系列其他癌症。进一步的受训者将致力于开发一种方法，以扩大在乳腺癌幸存者队列中的数据收集，并为结肠癌和子宫内膜癌幸存者开展类似的研究工作，以研究体力活动和体重的变化如何影响生存，以及这些生活方式与饮食、补充药物的使用、疲劳、抑郁和生活质量如何相关。

DESCRIPTION (provided by applicant): The K05 award will provide Dr. Leslie Bernstein with 40% protected time (20% research, 20% mentoring) to pursue research with mentees on associations between physical activity and body size (using height, weight, waist and hip measurements, independently, and various ratio measures like body mass index, waist-hip ratio, and waist-height ratio) and risk of breast, endometrial, ovarian, lung, colon, pancreas, bladder, rectal and thyroid cancer, non-Hodgkin's lymphoma and melanoma. Dr. Bernstein has a long successful career mentoring students (undergraduate, MS, PHD) and postdoctoral fellows, clinical fellows, and junior faculty at the University of Southern California (USC). At the City of Hope, Dr. Bernstein will focus on mentoring junior faculty and postdoctoral fellows within the Departments of Population Sciences, Medical Oncology, and Surgical Oncology to encourage their pursuit of questions in cancer prevention and control. She will continue mentoring PhD and MS students at USC where she is Professor Emerita, and MPH and PhD students at the Claremont Graduate University's new School of Community and Global Health. The research goal is to encourage mentees to focus on risk factors for cancer development or prognosis that are amenable to lifestyle intervention and to consider how those interventions might be implemented in a population. Specific mentoring goals are to foster mentees career advancement; provide opportunities for growth in cancer etiology and prevention; promote understanding of organizational cultures; guide development of research networks to facilitate career goals; and advise on how to prioritize and be efficient. Mentees will pursue new, unfunded areas of research under the Dr. Bernstein's careful guidance using the California Teachers Study cohort (CA077398, 6/1/04-5/31/09, Bernstein, PI) of 133,479 women followed for incident cancers since 1995. Cohort participants have completed 4 questionnaires thus far and have unique characteristics which include few smokers (5%), access to health care, high use of hormone therapy, diverse socioeconomic status and residential backgrounds, and unique reproductive histories. Mentees will work with Dr. Bernstein to pursue questions on the interaction between physical activity and body size measures to define risk and prognosis for breast cancer overall and by subtype, and where sufficient numbers exist, a series of other cancers. Further mentees will work to develop an approach to expand data collection in a cohort of breast cancer survivors and develop similar research efforts for colon and endometrial cancer survivors to study how changes in physical activity and body weight affect survival and how these lifestyle practices are associated with diet, use of complementary medicines, fatigue, depression, and quality of life.