Neuralynx for Translational Research

描述(申请人提供)：该项目的目标是购买一个最先进的系统，收集高带宽的多尺度神经生理学数据，以了解健康和疾病中人脑的功能网络。该设备将构成宾夕法尼亚大学神经科学、神经学、神经外科、心理学、计算神经科学和工程学领域多学科研究人员团队的核心。它还将极大地提高我们建立的国际多大学合作研究网络的生产率，该网络通过NINDS资助的国际癫痫神经生理学数据库收集和共享人类神经生理学数据，供全球研究使用。我们调查团队的主要研究领域包括癫痫、记忆和认知、听力、皮质发育不良和运动障碍。到目前为止，我们的合作小组一直非常富有成效，但主要依赖于其他地点收集的数据，如梅奥诊所和托马斯·杰斐逊大学医院。该设备包括一个256通道的Neuralynx数据采集和处理系统，以及48 TB的RAID存储，用于归档、处理和共享数据。该项目是宾夕法尼亚大学医学院和工程学院之间的密切合作，前者是在癫痫手术评估期间植入颅内电极的患者得到治疗的地方，后者是整个大学的研究人员，他们精心设计研究来查看来自这些患者的数据，而工程院则是收集、处理、归档和分析这类大型、高分辨率数据集的专业知识的所在地。购买这种设备将极大地扩大我们在宾夕法尼亚大学的合作小组，以及我们的研究成果，因为目前它受到来自其他机构的微电极数据的限制。我们还准备测试我们在宾夕法尼亚大学开发的令人兴奋的新型柔性有源电极设备的原型，NCRR奖的时间将与一些首批新的人体植入物同步。

DESCRIPTION (provided by applicant): The objective of this project is to purchase a state of the art system to collect high- bandwidth multi-scale neurophysiologic data to understand functional networks in the human brain in health and disease. The equipment will form the core of a multi- disciplinary team of investigators in the fields of Neuroscience, Neurology, Neurosurgery, Psychology, Computational Neuroscience, and Engineering at the University of Pennsylvania. It will also dramatically increase the productivity of an international, multi-university collaborative research network we have established to collect and share human neurophysiologic data for research worldwide through the NINDS-funded International Epilepsy Neurophysiology Database. Major areas of research focus in our investigative team include epilepsy, memory and cognition, hearing, cortical dysplasia and movement disorders. Our collaborative group has been extremely productive to date, but relies on data gathered primarily at other sites, such as the Mayo Clinic, and Thomas Jefferson University Hospital. The equipment consists of a 256 channel, Neuralynx data acquisition and processing system, and 48 Terabytes of RAID storage to archive, process and share data. The project is a close collaboration between the Penn School of Medicine, where patients implanted with intracranial electrodes during evaluation for epilepsy surgery will be cared for, investigators throughout the university who craft studies to look at data coming from these patients, and the School of Engineering, where expertise for collecting, processing, archiving and analyzing these types of large, high-resolution data sets resides. Purchasing this equipment will dramatically expand our collaborative group at UPenn, and our research output, as it is currently limited by the availability of microelectrode data from other institutions. We are also poised to test prototypes of exciting new flexible, active electrode devices we have developed here at Penn, and the timing of this NCRR award will be synchronized with some of these first new human implants.