Training Program in Neuroengineering and Medicine

 描述(由申请人提供)：我们的新的多学科机构培训计划，总部设在宾夕法尼亚大学医学院和工程学院，旨在培训神经工程学及其临床翻译方面的博士后研究生和博士后研究员。神经系统疾病，如中风、癫痫、帕金森氏病、抑郁症、痴呆症和头部创伤，占所有疾病和残疾的35%，而且负担正在上升。在成像、分析和调节神经回路的新技术中，针对这些疾病的有希望的治疗方法激增，但将这些治疗方法从实验室转换到患者身上是一个挑战。它需要受过临床科学教育的有才华的工程师和说同样语言、技术熟练的医生。这些研究人员必须共同驾驭复杂的科学、监管和临床环境。尽管需求巨大，但几乎没有正式的、跨学科的神经工程培训项目。我们提出了一个由宾夕法尼亚医学院和工程学院共享的新项目，重点是神经工程和临床翻译。医生和工程实习生将共同熟练掌握神经工程前沿技术，如设备、神经刺激、机器学习和算法开发；云计算、纳米技术和材料科学。他们将创新人类疾病的新疗法，并彻底了解将新技术安全地带给患者所需的临床、监管和开发环境。该项目的核心是一群协作的、多学科的工程学和临床神经科学教师导师。除了专门的神经工程研究，我们的培训计划还包括：(1)博士候选人的纵向临床指导经验；(2)工程实验室沉浸和博士后研究员辅导；(3)工程学、神经科学和医学的正式课程和研讨会；(4)正确进行研究的培训；以及(5)关于专业和职业发展的研讨会，包括科学写作、公开演讲、拨款撰写和实验室管理。该计划每年将从大约50名医学博士研究员和80-90名博士生中招募优秀人才。这一努力正式确定了一项合作，在过去的12年里，这项合作培训了一批令人印象深刻的神经工程研究人员。该项目在宾夕法尼亚大学是独一无二的，它利用了一流的研究和培训环境，包括一个紧凑的校园，在那里，强大的工程、医学和神经科学中心都位于彼此相隔两个街区的地方，通过宾夕法尼亚大学新的神经工程和治疗中心联系在一起。

 DESCRIPTION (provided by applicant): The aim of our new, multidisciplinary institutional training program, based in the Schools of Medicine and Engineering at the University of Pennsylvania, is to train pre-doctoral engineering students and physician postdoctoral fellows in Neuroengineering and its clinical translation. Disorders of the nervous system, such as stroke, epilepsy, Parkinson's disease, depression, dementia, and head trauma, constitute 35% of all disease and disability, and the burden is rising. There is an explosion of promising therapies for these disorders in new technologies to image, analyze, and modulate neural circuits, but translating these therapies from the laboratory to patients is a challenge. It requires talented engineers educated in clinical science and technically proficient physicians who speak the same language. Together these investigators must navigate a complex scientific, regulatory, and clinical landscape. Despite the huge demand, few formal, interdisciplinary Neuroengineering training programs exist. We propose a new program shared by the Penn Schools of Medicine and Engineering focused on Neuroengineering and Clinical Translation. Physician and Engineering trainees will together become fluent in cutting-edge technologies at the forefront of Neuroengineering, such as devices, neurostimulation, machine learning, and algorithm development; cloud computing, nanotechnology and materials science. They will innovate new therapies for human disease and gain a thorough understanding of the clinical, regulatory, and developmental environments necessary to safely bring new technologies to patients. The program's core is a group of collaborative, multidisciplinary faculty mentors in engineering and the clinical neurosciences. In addition to dedicated neuroengineering research, our training program includes: (1) a longitudinal mentored clinical experience for PhD candidates, (2) engineering lab immersion and tutorial for MD postdoctoral fellows, (3) formal courses and seminars in Engineering, Neuroscience and Medicine, (4) training in the proper conduct of research, and (5) workshops on professional and career development, including scientific writing, public presentations, grant writing, and laboratory management. The program will recruit from an excellent pool of ~50 MD fellows and 80-90 PhD students each year. This effort formalizes a collaboration that has trained an impressive array of Neuroengineering investigators over the past twelve years. The program, unique at Penn, leverages a superb research and training environment, including a compact campus where robust centers for Engineering, Medicine and Neuroscience all reside within two blocks of each other, united through Penn's new Center for Neuroengineering and Therapeutics.