Pathology and Tissue Core

有效的组织获取和利用对于有意义的转化研究活动至关重要。的 组织采购和血液病理学核心将与每个SPORE项目和生物统计学 和数据管理核心，以确保高效和高度协调的采购、使用和存储 血液和骨髓样本中心将获取并保存血液样本库（包括 外周血、骨髓活检和骨髓抽吸物）用于实验室使用，具有有效的 所有实验室标本的编码系统，以确保患者的保密性，并防止实验偏倚。 研究者、研究护士、生物统计学家和 血液病理学家，以及标准化的操作程序的活动将提供最佳的组织 每个样品的采集和准确处理、分析和储存。因此， 病理学和组织芯是为了便于临床样本的采集、保存、分析和分发。 样本，并为所有项目研究者提供血液病理学表征和标本。 组织获取和血液病理学核心有以下目标： 开发和维护血液和骨髓标本库，包括完整的细胞， 血清、细胞DNA、RNA和蛋白质，来自白血病和MDS患者（包括 新诊断、缓解和/或复发）在医学博士处接受护理或评估。Anderson 癌症中心将组织样本分发给SPORE研究人员进行分析，并提供 在SPORE项目中对组织切片进行研究的解释方面的专业知识提供 SPORE项目中使用的血液和骨髓样本的全面组织学表征， 包括来自进入临床方案的患者的样本。 为孢子研究人员提供库存和定制的反相蛋白质阵列。 维护一个包含详细临床和病理数据的全面、前瞻性交互式数据库 适用于在医学博士接受护理或评估的白血病和骨髓增生异常综合症患者安德森癌症中心 通过共享血液和骨髓资源促进SPORE间的合作。 摘要：有效的组织采购和利用对于有意义的转化研究至关重要 活动组织采购和血液病理学核心将与每个SPORE项目和 生物统计和数据管理核心，确保高效和高度协调的采购，使用和 血液和骨髓样本的储存

Effective tissue procurement and utilization is vital for meaningful translational research activities. The Tissue Procurement and Hematopathology Core will work with each SPORE project and the Biostatistics and Data Management Core to ensure efficient and highly-coordinated procurement, use and storage of blood and bone marrow samples. The Core will obtain and maintain a repository of blood samples (including peripheral blood, bone marrow biopsies, and bone marrow aspirates) for laboratory use, with an effective coding system for all laboratory specimens to ensure patient confidentiality and prevent experimental bias. Continuous communication between the investigators, research nurses, biostatisticians and hematopathologists, as well as standardized operating procedures for activities will provide for optimal tissue collection and accurate processing, analysis and storage of each sample. Thus, the functions of the Pathology and Tissue Core are to facilitate acquisition, preservation, analysis and dispersal of clinical samples and to provide hematopathologic characterization and specimens for all project investigators. The Tissue Procurement and Hematopathology Core has the following objectives: ¿ Develop and maintain a repository of blood and bone marrow specimens, including intact cells, serum, cellular DNA, RNA and protein, from patients with leukemia and MDS (including patients who are newly diagnosed, in remission and/or in relapse) receiving care or evaluation at M.D. Anderson Cancer Center. Distribute tissue specimens to SPORE investigators for analysis and provide expertise in the interpretation of studies performed on tissue sections within SPORE projects Provide comprehensive histologic characterization of blood and marrow samples used in SPORE projects, including specimens from patients entered onto clinical protocols. ¿ Provide stock and customized Reverse Phase Protein Arrays to Spore researchers. ¿ Maintain a comprehensive, prospective interactive database with detailed clinical and pathologic data for patients with leukemia and MDS receiving care or evaluation at M.D. Anderson Cancer Center ¿ Facilitate inter-SPORE collaborations through sharing of blood and marrow resources. Lay Abstract: Effective tissue procurement and utilization is vital for meaningful translational research activities. The Tissue Procurement and Hematopathology Core will work with each SPORE project and the Biostatistics and Data Management Core to ensure efficient and highly-coordinated procurement, use and storage of blood and bone marrow samples