ADMINISTRATIVE CORE

埃默里帕金森病协同环境研究中心(Emory)的中心主题 PD-CERC)是指暴露在环境毒物中会破坏线粒体功能和多巴胺 储存，导致氧化应激增加，这有助于帕金森氏症的发病 疾病。中枢神经系统项目对临床研究的关注是建立在 临床科学家和基础科学家。我们将在多个层面上建立和促进这些互动 我们的行政核心。米勒博士是一名神经毒理学家，将担任PI和 程序。米勒博士将与联席主任德龙博士密切合作。德龙博士是一位神经科医生 专门研究运动障碍。米勒博士和德龙博士将确保有丰富的互动 参与该项目的基础和临床科学家与大学里的其他人之间的关系。埃默里 大学因其在帕金森氏症方面的开创性翻译研究而受到国际认可。在……里面 2002年，米勒博士被招募到埃默里大学神经退行性疾病中心， 在埃默里帕金森氏病环境研究合作中心发挥了不可或缺的作用 或CCPDER(DeLong博士，P.I.)。我们将我们对CNS计划的应用视为 这个非常成功的研究项目。因此，我们将利用现有的行政结构 CCPDER为CNS项目提供领导，重点是翻译科学。这个 CND将作为这项研究计划的发起地。大多数调查人员都住在 并有一系列完善的研讨会和数据俱乐部，将促进在 埃默里PD-CERC。行政核心的目标如下：领导调查组 协作研究，向调查小组提供大学一级的投入和专业知识，以提供 向调查小组提供国家一级的专门知识和监督，并促进技术开发 (治疗学、预测模型、生物标志物)，可能有助于诊断、治疗和预后 帕金森氏症患者。通过追求这些目标，行政领导层将确保所有 项目团队朝着我们的CNS计划的共同目标前进，即整合临床和基础 研究以确定和减轻环境化学物质对帕金森氏症的不利影响。

The central theme of the Emory Parkinson's Disease Collaborative Environmental Research Center (Emory PD-CERC) is that exposure to environmental toxicants disrupts mitochondrial function and dopamine storage, which leads to increased oxidative stress, which contributes to the pathogenesis of Parkinson's disease. The CNS program's focus on clinical research is predicated upon close interactions between clinical scientists and basic scientists. We will establish and promote these interactions at multiple levels of our administrative core. Dr. Miller is a neurotoxicologist and will serve as PI and Director of the overall program. Dr. Miller will work closely with the Co-Director Dr. DeLong. Dr. DeLong is a neurologist specializing in movement disorders. Dr. Miller and Dr. DeLong will ensure that there are rich interactions between the basic and clinical scientists involved in the program and others at the university. Emory University is internationally recognized for its pioneering translational research in Parkinson's disease. In 2002, Dr. Miller was recruited to the Center for Neurodegenerative Disease (CND) at Emory University and played an integral role in the Emory Collaborative Center for Parkinson's Disease Environmental Research or CCPDER (Dr. DeLong, P.I.). We view our application to the CNS program as the natural continuation of this very successful research program. Thus, we will take advantage of the existing administrative structure of the CCPDER to provide leadership to the CNS program with an emphasis on translational science. The CND will serve as the home for this research initiative. The majority of the investigators are housed within the CND and there is a well-developed series of seminars and data clubs that will foster collaboration in the Emory PD-CERC. The objectives of the Administrative Core are as follows: to lead the investigative team in collaborative research, to provide University-level input and expertise to the investigative team, to provide national-level expertise and oversight to the investigative team, and to foster development of technologies (therapeutics, predictive models, biomarkers) that may benefit the diagnosis, treatment, and outcome of Parkinson's disease patients. By pursuing these objectives, the administrative leadership will ensure that all project teams track toward our common goal for the CNS Program, which is to integrate clinical and basic research to identify and mitigate the adverse impact of environmental chemicals in Parkinson's disease.