NEUROPEPTIDE BASIS OF SOCIAL LOSS AND DEPRESSION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 首先，我们描述了草原田鼠的基本育儿行为，并记录了母亲和父亲协调他们的养育行为，以最大限度地减少幼崽被单独留在巢中的时间。此外，单身母亲不会通过增加在巢中的时间或舔舔和梳理来弥补父亲的缺席。在第二项研究中，我们考察了双亲(BP)和单亲(SM)养育条件对下一代家庭动态的影响，发现SM养育的成年父母比BP养育的成年父母表现出更低的幼崽导向LG发生率。我们继续通过检查母亲的日常分离对晚年社会行为的影响来探索早期生活的社会扰动的影响。我们探索了催产素和CRF系统的相互作用关系，作为调节应激对社会行为影响的可能机制，以及社会损失对应激轴的影响。这导致了一个非常令人兴奋的发现，即CRF2受体几乎完全与催产素在大鼠和草原田鼠的下丘脑中共存。提示CRF2受体可能在催产素分泌调节中起重要作用。我们继续描述CRF和OT系统之间的神经解剖学关系，现在已经作为手稿提交给精神神经内分泌学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. First we characterized the basic parenting behavior in prairie voles and documented the both mother and fathers coordinate their parenting behaviors to minimize the amount of time that the pups are left unattended on the nest. Furthermore, single mothers do not compensate for the absence of the father by increasing time on the nest or licking and grooming. In a second study we examined the effects of biparental (BP) and single mother (SM) rearing conditions on family dynamics in the next generation and found that SM-reared adult parents exhibited lower rates of pup-directed LG in comparison to BP-reared counterparts. We continued to explore the effect of early life social perturbations by examining the effect of daily maternal separations on later life social behavior. We have explored the reciprocal relationship in oxytocin and CRF system as a possible mechanism regulating the effects of stress on social behaviors, as well as the effects of social loss on the stress axis. This has led to the very exciting discovery that the CRF2 receptor is virtually completely co-localized with oxytocin in the rat and prairie vole hypothalamus. This suggests that CRF2 receptor may play a major role in the regulation of oxytocin secretion. We have continued to characterize the neuroanatomical relationship between the CRF and OT system, which has now been submitted as a manuscript to Psychoneuroendocrinology.