CELLULAR IMMUNE RESPONSES TO ACELLULAR PERTUSSIS VACCINATION IN INFANTS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 疫苗接种是已知的在全世界预防死亡和疾病的最具成本效益的医疗和公共卫生干预措施。疫苗有助于延长预期寿命，减轻流行性腮腺炎、脊髓灰质炎、麻疹、风疹、白喉、破伤风和百日咳等儿童疾病的负担。然而，调节这些疫苗疗效的机制仍不清楚。事实上，总的来说，对婴儿接种疫苗的免疫反应了解很少，也没有用现代免疫学工具很好地研究。此外，大多数疫苗效力研究都集中在保护性抗体反应上，而对免疫后的细胞免疫和抗原特异性T细胞反应知之甚少。了解成功疫苗的免疫学基础将为设计针对结核病等复杂传染病的新疫苗提供重要的见解。这项研究的主要目标是检查新生儿在出生第一年接种无细胞百日咳疫苗后所产生的T细胞反应。 这项研究代表了儿科和庞塞中心的Rana Chakraborty博士与传染病部门和Emory疫苗中心的Rengarajan博士的密切合作，并利用了这两个小组现有的临床和基础科学专业知识和基础设施。通过这些探索性研究产生的数据将为未来关于疫苗诱导新生儿免疫的详细研究奠定基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Vaccination is the most cost-effective medical and public health intervention known to prevent death and disease worldwide. Vaccines have been instrumental in increasing life expectancy and reducing the burden of childhood diseases like mumps, polio, measles, rubella, diphtheria, tetanus and pertussis. However, the mechanisms that mediate the efficacy of these vaccines remain unclear. Indeed, in general, immune responses to vaccination in infants are poorly understood and have not been well studied with modern immunological tools. Moreover, most vaccine efficacy studies have focused on protective antibody responses and much less is known about cell-mediated immunity and antigen-specific T cell responses following immunization. Understanding the immunological basis of successful vaccines would provide important insights for designing new vaccines for complex infectious diseases like tuberculosis. The primary goal of this study is to examine neonatal T cell responses induced by acellular pertussis vaccination during the first year of life. This study represents a close collaboration between Dr. Rana Chakraborty at the Department of Pediatrics and the Ponce Center and Dr. Rengarajan at the Division of Infectious Disease and the Emory Vaccine Center and takes advantage of existing clinical and basic science expertise and infrastructure within the two groups. Data generated through these exploratory studies will lay the foundation for future detailed studies on vaccine-induced immunity in neonates.