EFFECTS OF REVERSIBLE INACTIVATION ON MEMORY AND BRAIN FUNCTIONAL ACTIVITY

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 内侧颞叶在记忆中的作用已经在动物和人类中使用神经成像进行了广泛的研究。 然而，如果类似的技术可以应用于验证与行为相关的神经活动，人类和动物研究之间的联系将得到加强。 只有在直接操作函数的情况下，才能得出因果关系的结论。我们建议联合收割机功能磁共振成像和可逆失活技术来研究清醒，行为恒河猴的海马在记忆中的作用。 该项目启动了一系列研究，将阐明记忆处理的神经基础，在非人类灵长类动物使用功能性磁共振成像（fMRI）和暂时失活的海马清醒行为的猴子使用新奇反应范例。通过允许评估短暂地将特定神经结构“离线”的影响，这些技术的组合将提供对内侧颞叶的正常功能的见解，这不能从单独使用永久性病变或功能磁共振成像的研究中获得。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The medial temporal lobe's role in memory has been extensively studied invasively in animals, and in humans using neuroimaging. However, the link between human and animal studies would be strengthened if similar techniques can be applied to verify the neural activity associated with behavior. Furthermore, only in directly manipulating function can causative conclusions be made. We propose to combine functional MRI and reversible inactivation techniques to study the roles of the hippocampus in memory in awake, behaving rhesus macaques. This project initiates a line of research that will elucidate the neural basis of mnemonic processing in nonhuman primates using functional magnetic resonance imaging (fMRI) and temporary inactivation of the hippocampus in awake behaving monkeys using a novelty response paradigm. By permitting assessment of the effects of briefly taking particular neural structures "offline" the combination of these techniques will provide insights into the normal function of the medial temporal lobes that cannot be obtained from studies using permanent lesions or fMRI alone.