UCLA Center for Excellence in Pancreatic Diseases

描述（由申请人提供）：加州大学洛杉矶分校胰腺疾病卓越研究中心是一个高度协作的多学科研究项目，旨在对胰腺疾病预防和治疗的补充和替代医学研究产生重大影响。植物药物和膳食补充剂对胰腺疾病的生物学作用机制以及对特定植物营养素反应的代谢表型特征可以为预防和治疗胰腺疾病的生物学基础实践提供理论依据。我们的中心包括来自加州大学洛杉矶分校校园，洛杉矶生物医学研究所在港-加州大学洛杉矶分校医学中心，和VA大洛杉矶医疗保健系统-西洛杉矶（VAGLAHS-WLA）的专家。该中心由经验丰富的胰腺疾病研究人员领导

DESCRIPTION (provided by applicant): The UCLA Center for Excellence in Pancreatic Diseases constitutes a highly collaborative, multidisciplinary research program designed to make a significant impact on the investigation of complimentary and alternative medicine in the prevention and therapy of pancreatic diseases. Biological mechanisms of action of botanicals and dietary supplements on pancreatic diseases and characterization of metabolic phenotypes in response to specific phytonutrients can form the rationale for biologically-based practices in the prevention and treatment of pancreatic diseases. Our Center includes expertise from the UCLA campus, LA BioMed Research Institute at Harbor-UCLA Medical Center, and VA Greater Los Angeles Healthcare System-West Los Angeles (VAGLAHS-WLA). The Center is led by experienced pancreatic disease researchers who have organized investigative teams to develop highly interactive and synergistic research programs. Our goal is to study the phytonutrient mechanism of action in both inflammatory and proliferative diseases of the pancreas in which we will use molecular biology and metabolomic technology to investigate altered cellular function. Characterization of metabolic phenotypes in response to specific phytonutrients can be measured by tracer metabolomics. These scientific programs will investigate the mechanisms of action of phytonutrients in both inflammatory and proliferative diseases of the pancreas utilizing both molecular biology tools and metabolomics technology. The projects will focus on: Project 1 - the effects of phytochemicals and metabolism in pancreatic diseases, Project 2 - role of polyphenols in regulating lipid inflammatory process in pancreatic cancer, and Project 3 - the effects of flavonoids on pancreatic carcinogenesis and angiogenesis. The projects will utilize our shared core resources including the Administrative Core, Animal Model Core, Phytonutrient Core, and Metabolomics Core. The Administrative Core includes a Biostatistics Sub-Core to provide biostatistical support to all the research projects and core functions, as well as the management of research and shared data functions of the Center. We also plan to select an External Advisory Board comprised of nationally and internationally recognized translational pancreatic disease researchers. The UCLA Center for Excellence is designed for maximum integration and synergy of research of key investigators who have been collaborating over the years so that the Center can be focused on the most promising investigations with the greatest NCCAM translational potential.