RESOURCE CORE 2: NUTRITION, METABOLISM, AND PHYSIOLOGY CORE

衰老过程及其伴随的健康问题与蛋白质、碳水化合物和脂肪代谢的复杂相互作用有关，这是阿肯色大学医学科学(UAMS)强有力的研究计划。这些代谢变化与体重的减轻有关，特别是与体重的减少有关。 骨骼肌质量以及骨骼肌和心肌的功能能力。与UAMS唐纳德·W·雷诺兹老龄化研究所的老龄化与长寿转化研究中心(CTral)合作，拟议的营养、代谢和生理学核心具有独特的执行能力 在老年人和啮齿类动物中进行的关于特定治疗措施对衰老和疾病期间体重、骨骼肌和心肌功能变化以及对其他代谢和生理终点的影响的创新、控制良好的研究。这一核心对于评估这些治疗措施的临床和功能后果至关重要。为了最大限度地发挥我们研究的解释价值，该核心将与其他核心直接对接，形成一个全面的资源，以确定营养补充或其他干预研究在老年人中的有效性。 致力于营养、新陈代谢和生理学研究的中央设施将为对衰老研究感兴趣的研究人员之间的互动提供一个有效的机制，并将提高资源的经济效率。临床评估工具将允许我们评估许多不同的领域 身体成分。标准化测试将使我们能够评估各个层面的功能，新陈代谢厨房设施将使我们能够支持营养干预和饮食。该中心和核心设施设在UAMS校园内的老龄研究所。这个核心的目标是为对衰老研究感兴趣并希望研究与衰老有关的营养、新陈代谢和生理学方面的研究人员提供一个合作的平台。通过这种方式，核心将为调查提供便利。美国国立卫生研究院资助的大量研究人员已经参与了与衰老相关的翻译研究， 核心将促进这一领域的持续增长和发展。

The aging process and its concomitant health issues in relation to the complex interplay of protein, carbohydrate, and fat metabolism represent strong research initiatives at the University of Arkansas for Medical Sciences (UAMS). These metabolic changes are related to the loss of body weight, specifically loss of skeletal muscle mass and skeletal and cardiac muscle functional capabilities. In conjunction with the Center for Translational Research in Aging & Longevity (CTRAL) at the Donald W. Reynolds Institute on Aging at UAMS, the proposed Nutrition, Metabolism, and Physiology Core has a unique ability to perform innovative, well-controlled studies in elderly human and rodents regarding the influence of specific therapeutic measures on changes in body weight and skeletal and cardiac muscle function during aging and disease as well as on other metabolic and physiologic endpoints. This Core is essential to assess the clinical and functional consequences of these therapeutic measures. To maximize the interpretative value of our studies, this Core will interface directly with the other cores to form a comprehensive resource to establish efficacy of nutrient supplementation or other intervention studies in the elderly. A centralized facility devoted to Nutrition, Metabolism, and Physiology research will provide an efficient mechanism for interaction among investigators interested in aging research and will enhance economically efficient utilization of resources. Clinical assessment tools will allow us to evaluate many different domains of body composition. Standardized tests will allow us to evaluate function on every level, and metabolic kitchen facilities will enable us to support nutritional interventions and diets. The CTRAL and the Core facilities are housed at the Institute on Aging on the UAMS campus. The goal of this Core is to provide a platform for collaboration for investigators who are interested in aging research and want to study aspects of nutrition, metabolism, and physiology in relation to aging. In this manner, the Core will facilitate investigations. A significant number of NIH-funded investigators are already involved in aging-related translational research, and the Core will facilitate continual growth and development in this area.