LSUHSC COBRE: IMMUNE CORRELATES OF BKV PERSISTENCE AND REACTIVATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 子项目#2：BKV持久性和再激活的免疫相关性 John A.旺希埃 BK病毒（BKV）已成为肾和干细胞移植受者发病的重要原因，这一出现强调了我们对这种普遍存在的病毒的自然史的认识存在重大缺陷。 BKV的无症状再激活和脱落在免疫受损期间（包括妊娠）很常见，但通常维持BKV潜伏期的宿主免疫因素知之甚少。 妊娠期间BKV再激活为探索与BKV脱落相关的免疫激活以及影响儿童早期BKV传播的宿主因素提供了独特的机会，而没有与器官移植和严重免疫受损相关的混杂因素。 这一建议的中心假设是，母体免疫因素有助于BKV在怀孕期间的重新激活，最终影响BKV从母亲到孩子的传播。 这些研究将确定人类BKV感染的自然史，包括确定婴儿早期促进BKV传播的事件，响应母体BKV再激活的免疫途径以及婴儿对BKV感染的免疫反应。 进一步了解BKV感染的自然史对BKV相关疾病的发病机制和治疗的未来研究至关重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Subproject #2: Immune Correlates of BKV Persistence and Reactivation John A. Vanchiere BK virus (BKV) has emerged as an important cause of morbidity in kidney and stem cell transplant recipients, and this emergence has underscored the significant deficits in our knowledge of the natural history of this ubiquitous virus. Asymptomatic reactivation and shedding of BKV is common during periods of immune compromise, including pregnancy, but the host immune factors that normally maintain BKV latency are poorly understood. BKV reactivation during pregnancy presents a unique opportunity to explore the immune activation associated with BKV shedding and the host factors that influence transmission of BKV during early childhood without the confounding factors associated with organ transplantation and severe immune compromise. The central hypothesis of this proposal is that maternal immune factors contribute to the reactivation of BKV during pregnancy, ultimately influencing the transmission of BKV from mother to child. These studies will define the natural history of BKV infection in humans, including the identification of events in early infancy that facilitate BKV transmission, the immune pathways activated in response to maternal BKV reactivation and the infant immune response to BKV infection. An improved understanding of the natural history of BKV infection is crucial to the development of future studies of the pathogenesis and treatment of BKV-related disease.