CELL SIGNALING IN INTESTINAL EPITHELIAL CELLS FROM WOUND HEALING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 研究目标 研究肠上皮细胞中某些蛋白激酶C家族酶的表达及其在伤口愈合中的作用。具体的重点将放在经典的异构体<$和<$和新的异构体<$。 检查皮质类固醇和溶血磷脂酸暴露对蛋白激酶C同工酶（<$、<$、<$）表达的影响及其对肠上皮伤口愈合率的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Research Goals Investigate the expression and role of some of the protein kinase C family of enzymes on wound healing in intestinal epithelial cells. Specific emphasis will be placed on the classical isoforms ¿ and ¿ and the novel isoform ¿. Examine the effect of corticosteroid and lysophosphatidic acid exposure on the expression of protein kinase C isozymes (¿, ¿, ¿) and their impact on rates of wound healing in intestinal epithelium.