HIGH-RESOLUTION FMRI OF HIPPOCAMPAL SUBFIELD CONTRIBUTIONS TO EPISODIC MEMORY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 情景记忆个别事件记忆允许有机体将过去与现在联系起来，提供有关先前事件的信息，这些信息用于通知当前的决定和行动。情节记忆主要依赖于内侧颞叶（MTL）回路，该回路由多个结构组成，包括海马结构[齿状回（DG），CA场和下托（DG）]以及周围的内嗅（ERc），嗅周（PRc）和海马旁（PHc）皮质。虽然几十年的研究旨在描述MTL在情景记忆中的作用，但关于特定MTL子结构的功能贡献的基本问题仍然存在。功能成像方法的最新进展使解决人类的这些问题成为可能。我们的研究使用高分辨率的功能磁共振成像描绘的作用，海马子字段和MTL皮层结构的编码和提取的情节记忆。实验测试解剖学告知理论驱动的假设，情节记忆的性质和依赖MTL功能。本研究进一步探讨了最佳的学习参数，以促进情景记忆的灵活性，生成性使用，以及动机的显着性和注意力对情景记忆处理和MTL功能的潜在影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Episodic memorymemory for individual eventspermits an organism to bridge the past with the present, providing information about prior events that serves to inform present decisions and action. Episodic memory critically depends on the medial temporal lobe (MTL) circuit, which is composed of multiple structures, including the hippocampal formation [dentate gyrus (DG), CA fields, and subiculum (SUB)] and the surrounding entorhinal (ERc), perirhinal (PRc), and parahippocampal (PHc) cortices. Though decades of research have aimed to characterize the role of MTL in episodic memory, fundamental questions remain regarding the functional contributions of specific MTL substructures. Recent advances in functional imaging methods have made it possible to address these questions in humans. Our research uses high-resolution fMRI to delineate the role of hippocampal subfields and MTL cortical structures in the encoding and retrieval of episodic memories. The experiments test anatomically-informed theory-driven hypotheses regarding the nature of episodic memory and its dependence on MTL function. The research further examines optimal learning parameters to promote the flexible, generative use of episodic memory, and the potential impact of motivational salience and attention on episodic memory processing and MTL function.