ENERGY METABOLISM AND BRAIN CHANGES WITH AGE AND ALZHEIMER'S DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 候选人是一名老年神经学家，接受过痴呆症和阿尔茨海默病（AD）的博士后培训，他将使用K23开发临床研究方法，先进的神经影像技术和代谢方面的专业知识。该提案结合了候选人在痴呆症临床评估，脑结构变化的神经影像学研究以及对代谢的新关注方面的经验。学术环境将通过Hoglund脑成像中心，能量平衡实验室，生物统计学和生物信息学中心以及NIH赞助的K30课程培训计划来支持培训和研究经验。职业发展：候选人将获得临床研究硕士学位，接受新陈代谢和身体成分评估培训，以及高级神经成像技术培训和正式课程。研究项目：对热量限制和胰岛素代谢的研究使我们对衰老过程的理解取得了重大进展，并将能量代谢作为与年龄相关的疾病（如AD）的潜在病因。该研究计划的总体目标是检验外周能量代谢影响大脑衰老的假设。使用从候选人的博士后培训计划完善的临床和神经影像学方法，标准的方法，临床表征和神经成像老年人有和没有记忆问题将开发，试点，并实施（目标1）。将在一组非痴呆（n = 32）和早期AD受试者（n = 32）中对脑结构与胰岛素介导的葡萄糖处置（目标2）和静息代谢率（目标3）的关系进行横断面检查。对脑结构变化的生理介质的进一步了解可能会为促进脑健康和预防与年龄相关的脑疾病带来新的治疗靶点。K23的支持将使候选人能够建立一个研究和教育基础，利用神经成像技术开发和启动一个独立的以患者为导向的职业生涯，以研究与年龄相关的脑结构变化和AD等脑部疾病的病理生理学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The candidate is a geriatric neurologist with postdoctoral training in dementia and Alzheimer's disease (AD) who will use the K23 to develop expertise in clinical research methodology, advanced neuroimaging techniques, and metabolism. The proposal combines the candidate's experience in the clinical evaluation of dementia, neuroimaging research on structural brain changes, and a new focus on metabolism. The academic environment will support the training and research experience through the Hoglund Brain Imaging Center, the Energy Balance Laboratory, the Biostatistics and Bioinformatics Center, and an NIH-sponsored K30 curriculum training program. Career Development: The candidate will obtain a Master's in Clinical Research, training in the assessment of metabolism and body composition, and training and formal coursework in advanced neuroimaging techniques. Research Program: Research into caloric restriction and insulin metabolism have led to seminal advances in our understanding of aging processes and have implicated energy metabolism as an underlying etiology for age-related disease such as AD. The overall goal of the research program is examine the hypothesis that peripheral energy metabolism influences brain aging. Using well-established clinical and neuroimaging methods from the candidate's postdoctoral training program, standard methods to clinically characterize and neuroimage older adults with and without memory problems will be developed, piloted, and implemented (aim 1). The relationship of brain structure with insulin-mediated glucose disposal (aim 2) and resting metabolic rate (aim 3) will be cross-sectionally examined in a cohort of nondemented (n = 32) and early-stage AD participants (n = 32). Improved understanding of the physiologic mediators of structural brain changes may lead to new therapeutic targets for promoting brain health arid preventing age-related brain disease. K23 support will allow the candidate to build a research and educational foundation to develop and launch an independent patient-oriented career using neuroimaging to study the pathophysiology of age-related structural brain changes and brain disease such as AD.