Investigating Gains in Neurocognition in an Intervention Trial of Exercise
研究运动干预试验中神经认知的收益
基本信息
- 批准号:9816952
- 负责人:
- 金额:$ 287.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-15 至 2021-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAerobic ExerciseAge-YearsAge-associated memory impairmentAlzheimer&aposs DiseaseAmyloidAmyloid beta-ProteinAnimalsAttenuatedBiological MarkersBlindedBostonBrainBrain-Derived Neurotrophic FactorCardiovascular PhysiologyClinical TrialsCognitionCognitiveCognitive deficitsCollectionControl GroupsDNA MethylationDementiaDepositionDoseEffectivenessElderlyEpisodic memoryExerciseExhibitsFundingGenetic Predisposition to DiseaseGerontologyHealthHippocampus (Brain)HumanImageImpaired cognitionIncidenceIndividualInflammatoryInsulin ResistanceInterventionIntervention TrialLightMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasurementMeasuresMediatingMethodsMonitorNerve DegenerationNeurocognitionNeurosciencesObesityOutcomeOxidative StressParticipantPathologic ProcessesPathologyPhasePhase III Clinical TrialsPhysical FunctionPhysical activityPhysiologicalPositron-Emission TomographyPreventionPublic HealthQuality of lifeRandomizedRandomized Clinical TrialsReportingRiskSafetySamplingScanningScienceSiteStretchingSupervisionTestingTimeabeta accumulationabeta depositionactigraphyadherence rateamyloid pathologyapolipoprotein E-4arterial stiffnessbrain healthcardiometabolismcardiorespiratory fitnesscardiovascular fitnesscostcytokinedesigneffective therapyexercise interventionexercise prescriptionexercise trainingfollow-upgenome analysisimprovedintervention effectlaboratory facilitylight intensitymild cognitive impairmentneurotrophic factorwhole genome
项目摘要
1 Abstract.
2 In this competing revision we propose to expand the scope of the currently funded multi-site
3 Phase III clinical trial, IGNITE (Investigating Gains in Neurocognition in an Intervention Trial of
4 Exercise) to include measurement of Aβ following a 12-month physical activity (PA) intervention.
5 Despite an appreciation for the importance of Aβ accumulation in AD, there are currently no
6 effective treatments to slow or reverse deposition. Moderate intensity PA is one of the most
7 promising non-pharmaceutical approaches for mitigating age-related cognitive decline and
8 reducing risk for neurodegenerative conditions like AD. Unfortunately, the effectiveness of PA
9 remains a matter of continued skepticism because of the lack of a well-controlled Phase III
10 clinical trial. To address this continued skepticism, our team developed a Phase III clinical trial
11 called IGNITE (Investigating Gains in Neurocognition in an Intervention Trial of Exercise). This
12 study, funded in 2016, was designed to definitively address whether PA improves cognitive and
13 brain health. The IGNITE study was designed to address several major questions including
14 whether the presence of Aβ moderates the impact of the exercise intervention on cognitive or
15 other brain outcomes (e.g., hippocampal volume). The IGNITE study was also designed to
16 examine potential mechanisms of exercise on the brain. We have a unique opportunity to add
17 PET Aβ at follow-up to the ongoing IGNITE study which will allow us to test a number of critical
18 aims. Thus, this competing revision will leverage the size and rigor of the IGNITE trial (N = 639)
19 to examine whether 12 months of moderate intensity PA modifies Aβ pathology among
20 cognitively healthy older adults. Specifically, we will test: (a) whether a 12-month PA
21 intervention attenuates Aβ levels compared to a non-aerobic control group and (b) whether
22 changes occur in a dose-dependent manner. We will also test whether changes in Aβ mediate
23 exercise-induced changes in cognition and will test whether exercise-induced changes in
24 cardiometabolic, inflammatory, and neurotrophic factors statistically mediate changes in Aβ
25 burden. This proposal represents a unique opportunity to resolve whether PA could be applied
26 as a low cost, easily disseminated approach to mitigate Aβ accumulation. The outcomes of
27 IGNITE will have enormous implications for the way we approach treatment and prevention of
28 AD, and has the potential to advance the fields of gerontology, neuroscience, and public health.
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1摘要。
2在这一相互竞争的修订中,我们建议扩大目前资助的多地点
3第三阶段临床试验,IGNITE(调查在神经认知的干预试验中的收益,
4运动),包括12个月体力活动(PA)干预后的Aβ测量。
5尽管认识到Aβ积累在AD中的重要性,但目前没有
6种有效的治疗方法来减缓或逆转沉积。中等强度PA是最常见的
7种有前途的非药物方法,用于减轻与年龄相关的认知能力下降,
8降低神经退行性疾病如AD的风险。然而,PA的有效性
由于缺乏控制良好的第三阶段,
10临床试验为了解决这种持续的怀疑,我们的团队开发了一项III期临床试验,
IGNITE(Investigating Gains in Neurocognition in an Intervention Trial of Exercise,运动干预试验中神经认知的研究)这
2016年资助的12项研究旨在明确PA是否能改善认知和
13脑健康IGNITE研究旨在解决几个主要问题,包括
14 Aβ的存在是否缓和了运动干预对认知或
15其他大脑结果(例如,海马体积)。IGNITE研究还旨在
16研究锻炼对大脑的潜在机制。我们有一个独特的机会,
在正在进行的IGNITE研究的随访中,17例PET Aβ,这将使我们能够测试一些关键的
18个目标因此,这项竞争性修订将利用IGNITE试验的规模和严格性(N = 639)
19检查12个月的中等强度PA是否改变了Aβ病理学,
20名认知健康的老年人。具体而言,我们将测试:(a)12个月的PA是否
与非有氧对照组相比,干预减弱了Aβ水平,以及(B)是否
22种变化以剂量依赖性方式发生。我们还将检测Aβ的变化是否介导了
23运动引起的认知变化,并将测试是否运动引起的变化,
24种心脏代谢、炎症和神经营养因子在统计学上介导Aβ的变化
25负担这一建议是解决是否可以适用PA的独特机会
26作为一种低成本、易于推广的方法来缓解Aβ蓄积。的成果
IGNITE将对我们治疗和预防糖尿病的方式产生巨大影响。
28 AD,并有潜力推进老年学,神经科学和公共卫生领域。
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项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JEFFREY Murray BURNS其他文献
JEFFREY Murray BURNS的其他文献
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{{ truncateString('JEFFREY Murray BURNS', 18)}}的其他基金
Multidisciplinary Research Training Program in Alzheimer's Disease and Related Disorders
阿尔茨海默病及相关疾病多学科研究培训计划
- 批准号:
10672283 - 财政年份:2022
- 资助金额:
$ 287.76万 - 项目类别:
Remote Monitoring and Virtual Collaborative Care for Hypertension Control to Prevent Cognitive Decline
远程监控和虚拟协作护理控制高血压以防止认知能力下降
- 批准号:
10451202 - 财政年份:2020
- 资助金额:
$ 287.76万 - 项目类别:
Remote Monitoring and Virtual Collaborative Care for Hypertension Control to Prevent Cognitive Decline
远程监控和虚拟协作护理控制高血压以防止认知能力下降
- 批准号:
10045856 - 财政年份:2020
- 资助金额:
$ 287.76万 - 项目类别:
Remote Monitoring and Virtual Collaborative Care for Hypertension Control to Prevent Cognitive Decline
远程监控和虚拟协作护理控制高血压以防止认知能力下降
- 批准号:
10468992 - 财政年份:2020
- 资助金额:
$ 287.76万 - 项目类别:
Remote Monitoring and Virtual Collaborative Care for Hypertension Control to Prevent Cognitive Decline
远程监控和虚拟协作护理控制高血压以防止认知能力下降
- 批准号:
10693852 - 财政年份:2020
- 资助金额:
$ 287.76万 - 项目类别:
Aligning PCPs and Patients with Alzheimer's Research Efforts: MyAlliance for Cognitive Health
协调 PCP 和患者参与阿尔茨海默病的研究工作:MyAlliance for Cognitive Health
- 批准号:
10406998 - 财政年份:2020
- 资助金额:
$ 287.76万 - 项目类别:
Enhanced Mediterranean Diet for Alzheimer's Disease Prevention
强化地中海饮食预防阿尔茨海默病
- 批准号:
9579375 - 财政年份:2018
- 资助金额:
$ 287.76万 - 项目类别:
Enhanced Mediterranean Diet for Alzheimer's Disease Prevention
强化地中海饮食预防阿尔茨海默病
- 批准号:
10177834 - 财政年份:2018
- 资助金额:
$ 287.76万 - 项目类别:
Enhanced Mediterranean Diet for Alzheimer's Disease Prevention
强化地中海饮食预防阿尔茨海默病
- 批准号:
10403990 - 财政年份:2018
- 资助金额:
$ 287.76万 - 项目类别:
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