COMPUTATIONAL FLUID DYNAMICS FOR THE HEMODYNAMIC INVESTIGATION OF PEDIATRIC CAR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的目标是继续我们的计算流体动力学(CFD)研究(I)表征胚胎发育中期时间点的血流动力学负荷，作为我们小组最近记录的基线数据的扩展，ii)开发和验证我们的内部高分辨率浸入边界CFD解算器，用于在低Re数状态下的胚胎特定的形态，iii)了解和量化失败的Fontan患者组的次优生理状态，作为我们先前的研究的扩展，该研究确定了功能健康的患者的腔静脉波形驱动的能量学，iv)设计交互式手术计划方法，以使网络生成的智能能够在关键时间辅助手术决策过程，患者特有的冠状动脉搭桥术。最重要的是，我们计划利用PSC资源为我们的NSF-Carrer，这很可能是在2010年授予(修订预算和最终批准正在等待NSF)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. we aim to continue our computational fluid dynamics (CFD) studies (i) to characterize the hemodynamic loading at the intermediate embryonic development time points as an extension of the baseline data that was recently documented by our group, ii) develop and validate our in-house high resolution immersed boundary CFD solver for embryonic subject-specific morphologies at low Re number regimes, iii) to understand and quantify the suboptimal physiological state of the failing Fontan patient group as an extension of our previous study that identified the caval waveform driven energetics of the functionally healthy patients , iv) to design interactive surgical planning methods to enable cyber generated intelligence for aiding surgical decision making process in time critical, patient specific coronary artery bypass (CABG) operations. Most importantly we plan to utilize PSC resources for our NSF-CARRER which is likely to be awarded in 2010 (Revised budget and final approval is pending NSF).