SPECTROSCOPIC SCANNER FOR COMPREHENSIVE ASSESSMENT OF SURGICAL EXCISION MARGINS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目是制造和初步验证的定量光谱扫描仪，以全面评估手术切缘。我们将设计和建造一台定量光谱成像仪，用于评估体外组织的生化和形态信息。广域定量光谱数据采集将通过机械扫描类似于在各种LBRC临床应用中广泛使用的FastEEM探头的光学光谱探头来实现。仪器性能将在实验室环境中进行充分的表征和优化。将在临床上部署优化的临床仪器，用于评估乳房切除边缘的可行性研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is to fabricate and initial validatation of a quantitative spectroscopic scanner for comprehensive assessment of surgical margins. We will design and construct a quantitative spectroscopic imaging instrument for assessing ex vivo tissue biochemical and morphological information. The wide area quantitative spectroscopic data acquisition will be achieved by mechanically scanning an optical spectroscopic probe similar to the FastEEM probe extensively used in various LBRC clinical applications. Instrument performance will be fully characterized and optimized in the laboratory setting. An optimized clinical instrument will be deployed clinically for feasibility studies in assessment of breast excision margins.