MECHNISMS UNDERLYING HYPOXIA OR HYPEROXIA TOLERANCE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 缺氧和氧化应激与许多临床病症有关。本研究以果蝇为模型，探讨其耐缺氧或耐高氧的机制。该项目的中心目标是确定基因和途径，赋予果蝇耐缺氧或耐高氧。我们的长期目标是在哺乳动物中唤起这种机制，以保护敏感的哺乳动物细胞免受缺氧或高氧损伤。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Oxygen deprivation and oxidative stress are related to numerous clinical conditions. In this project, we use Drosophila model to investigate mechanisms underlying hypoxia or hyperoxia tolerance. The central aim of this project is to identify genes and pathways that confer hypoxia or hyperoxia tolerance in Drosophila. Our long-term goal is to evoke such mechanisms in mammals to protect sensitive mammalian cells from hypoxic or hyperoxic injury.