EVALUATION OF QUALITY OF MACROMOLECULAR CRYSTALS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 BioCARS正在提供晶体评估会议，在这种会议上，波束时间在短时间内分配给当地用户团体，以测试和评估他们的新晶体。任何结晶学项目的关键部分都是对晶体质量和新的晶体形态进行优化和评估。这一过程通常是在家庭机构的旋转阳极上费力地完成的。我们建议继续在14区提供这样的评估。非常强的同步辐射X射线源提供了重要的优势：它极大地加速了这一过程，获得的衍射图像提供了更好的晶体质量指示，并且可以对小的或弱的衍射晶体进行测试。 事实证明，我们以前的评估会议对当地用户非常受欢迎和有价值。我们只向已经注册并接受过当前培训的APS用户提供这些课程，因此根据这项建议收集的一些数据也可以与其他一般用户建议相关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. BioCARS is offering crystal evaluation sessions where beamtime is allocated on a short notice to local user groups to test and evaluate their new crystals. A critical part of any crystallographic project is optimization and evaluation of crystal quality and new crystal forms. This process is usually painstakingly done on a rotating anode at the home institution. We propose to continue with offering such evaluation at the Sector 14. Very intense synchrotron X-ray source provides important advantages: it greatly speeds up the process, obtained diffraction images provide better indication of crystal quality and testing of small or weakly diffracting crystals becomes possible. Our previous evaluation sessions have proven very popular and valuable to local users. We are offering these sessions only to already registered APS users with current training, so some of the data collected under this proposal could also be associated with other general user proposals.