MULTIMODAL EVALUATION OF PHOTOSENSITIVE EPILEPSY IN BABOONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项题为“蝙蝠光敏性癫痫潜在网络的多模式评估”的研究正在作为NIH探索/发展研究资助计划(R21 Parent)提交供审查(PA-06-181)。人类全身性癫痫的发病机制尚不清楚。本研究的目的是将功能神经成像确定的局部血流变化与脑内植入电极记录到的自发癫痫放电和光性癫痫反应相关联，最终目的是识别光敏感型全身性癫痫的潜在网络。除了间歇性光刺激外，我们还将利用经颅磁刺激来评估运动皮质和视觉皮质激活对癫痫网络的各自贡献。这项研究将产生初步数据，用于使用结构方程模型分析光敏性和健康的狒狒的视觉和运动连接。它还将确定负责产生自发癫痫放电和光性癫痫反应的候选区域，用于硬膜下格栅或微电极阵列植入。通过多模式方法，我们的目标是建立一个光敏性全身性癫痫的模型，该模型可用于评估新的抗癫痫药物或神经外科干预措施的生物学效应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study titled "Multimodal Evaluation of Networks Underlying Photosensitive Epilepsy in Baboons" is being submitted as a NIH Exploratory/Developmental Research Grant Program (R21 Parent) for review (PA-06-181). The mechanisms underlying generalized epilepsy in humans are still unknown. The objective of this study is to correlate regional blood flow changes identified by functional neuroimaging with spontaneous epileptic discharges and photoepileptic responses recorded by intracranially implanted electrodes, with the eventual goal of identifying in networks underlying the photosensitive generalized epilepsy of the baboon. We will also utilize transcranial magnetic stimulation in addition to intermittent light stimulation to evaluate the respective contribution of motor and visual cortex activations to the epileptic networks. This study will generate preliminary data for the analysis of visual and motor connectivity in photosensitive and healthy baboons using structural equation modeling. It will also determine candidate regions responsible for the generation of spontaneous epileptic discharges and photoepileptic responses for subdural grid or microelectrode array implantation. With a multimodal approach, we aim to develop a model for photosensitive generalized epilepsy which can be implemented for the evaluation of the biological effects of new antiepileptic medications or neurosurgical interventions.