IMMUNE RESPONSES TO TUBERCULOSIS IN HIV POSITIVE AND HIV NEGATIVE INDIVIDUALS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 随着艾滋病大流行继续加剧全球结核病(TB)的发病率，重要的是了解人类免疫系统在艾滋病毒阳性和HIV阴性的情况下如何应对结核病。这对于设计预防结核病的疫苗至关重要。由CD4+和CD8+T细胞介导的完整的获得性免疫应答对于控制结核分枝杆菌(Mtb)感染是必不可少的，但其效应功能、向记忆细胞的发育及其调节作用尚不清楚。我们正在描述结核病特异性免疫反应的进展及其在接受抗生素治疗的个体中的调节。 我们正在研究在标准的结核病抗生素治疗之前和期间，HIV阴性和HIV阳性患者的结核分枝杆菌抗原特异性免疫反应的调节。这些研究的患者登记正在格雷迪医院进行，基础科学(Rengarajan)和临床(RAY)研究人员密切合作。由于不存在纵向跟踪结核病和艾滋病毒-结核病混合感染患者的详细免疫学研究，该项目将为未来在更大患者群体中进行研究奠定基础，特别是在艾滋病和结核病共同流行的环境中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. As the AIDS pandemic continues to fuel rates of tuberculosis (TB) worldwide, it is important to understand how the human immune system responds to TB in both HIV-positive and HIV-negative settings. This is critical for designing vaccines that protect against TB disease. Intact adaptive immune responses mediated by CD4+ and CD8+ T cells are essential for controlling infection with Mycobacterium tuberculosis (Mtb) but their effector functions, development into memory cells and regulation are poorly characterized. We are characterizing the progression of TB-specific immune responses and their regulation within an individual undergoing antibiotic treatment. We are studying the regulation of Mtb antigen-specific immune responses in HIV negative and HIV positive individuals before and during standard tuberculosis antibiotic therapy. Patient enrollment for these studies is ongoing at Grady Hospital in close partnership between basic science (Rengarajan) and clinical (Ray) investigators. Since detailed immunological studies that longitudinally follow TB and HIV-TB co-infected patients do not exist, this project will lay the foundation for future studies in larger patient populations, specifically in settings where AIDS and TB are co-endemic.