LB/CV-N AND RC101 PRIMATE TESTING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 为了防止艾滋病毒和其他性病的持续传播，必须开发有效的局部杀微生物剂产品并提供使用。该项目建议开发一种组合局部杀微生物剂产品，主要针对预防艾滋病毒的传播，同时也具有预防其他性传播疾病的活性。该产品将由新型化合物（一种肽和一种融合抑制剂）组成，这些化合物相互之间发挥协同作用，从而从尽可能多的角度攻击病原体，同时保持直肠和阴道环境的完整性和微生物群。 产品配方由反复的安全性、毒性和有效性试验（体外、离体和体内）指导。我们的猕猴模型用于确定最可行和最有效的递送机制、化合物可用性和产品安全性。在猕猴模型中的这些实验对于填补实验室和临床研究之间的差距是必不可少的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In order to prevent the ongoing spread of HIV and other STDs, it is imperative that an effective topical microbicide product be developed and made available for use. This project proposes to develop a combination topical microbicide product, targeted primarily at preventing the transmission of HIV, and also have activity in preventing other STDs. The product will be made up of novel compounds (a peptide and a fusion inhibitor) which exert synergistic effects on one another, thereby attacking pathogens from as many angles as possible, while preserving the integrity and microflora populations of the rectal and vaginal environments. Product formulation is guided by iterative safety, toxicity and efficacy assays (in vitro, ex vivo and in vivo). Our macaque model is used to determine the most feasible and effective delivery mechanisms, compound availability and product safety. These experiments in the macaque model are essential in filling the gap between laboratory and clinical studies.