USE OF AN ORGANOPHOSPHORUS (OP) HYDROLASE FOR ACUTE OP TOXICITY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该基金的目的是在NHP模型中测试新型有机磷农药降解酶OpdA的安全性和有效性。证明这种酶对敌敌畏和敌敌畏是安全有效的，应该为人类使用的进一步发展提供必要的动力。我们的中心假设是，OpdA是安全的，并提高与敌敌畏和敌敌畏中毒后的生存。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this grant is and to test the safety and efficacy of a novel organophosphorus pesticide degrading enzyme, OpdA, in an NHP model. Proof that the enzyme is safe and effective against parathion and dichlorvos should provide the necessary impetus for further development for human use. Our central hypothesis is that OpdA is safe and improves survival after poisoning with parathion and dichlorvos.