SECULAR TREND OF BODY WEIGHT INCREASE AND EARLY PUBERTY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：探讨本群体猕猴体重增长和青春期提前的长期趋势。 在30年的研究过程中，实验动物的初潮年龄逐渐变小，但初潮时的体重是相同的。因此，我们假设在我们的群体猴中存在体重增加和青春期提前的长期趋势。 对殖民地记录的广泛分析表明，在过去30年中，雌性和雄性的体重增长曲线逐渐左移。此外，在此期间，殖民地女性的初潮年龄也变得显着年轻。对这一时期喂养计划的分析进一步表明，我们目前殖民地的猴子比30年前喂养的热量更高。在WNPRC群猴中，肥胖和初潮在年轻时出现的长期趋势与人类社会的趋势惊人地相似。体重对青春期的影响机制仍有待研究。 这项研究使用WNPRC动物服务和信息服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To investigate whether there is any secular trend in body weight increase and early timing of puberty in rhesus monkeys in our colony. During the course of the 30-year studies, the age of menarche in experimental animals had become gradually younger, yet the body weight at menarche was the same. Thus, we have hypothesized that there is a secular trend in body weight increase and early onset of puberty in our colony monkeys. Extensive analysis of the colony records indicates that the body weight growth curve gradually left-shifted during the past 30 years in both females and males. Moreover, the age of menarche in colony females also became significantly younger during this period. Analysis of feeding programs during this period further suggested that monkeys in our current colony were fed a higher calorie diet than those 30 years ago. This secular trend towards obesity and menarche at younger ages in the WNPRC colony monkeys is strikingly similar to the trend in human society. The mechanism of body weight impact on puberty remains to be investigated. This research used WNPRC Animal Services and Information Services.