ESTROGEN RECEPTOR-ALPHA CONTAINING NEURONS IN THE BRAINSTEM AND SPINAL CORD

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：测定雌激素受体α在去卵巢雌猴脑干和脊髓中的分布，以了解雌激素在女性健康中的作用。 由于灵长类动物和啮齿类动物性行为中的雌激素依赖性不同，因此灵长类动物脑干和脊髓中雌激素受体的分布模式也有很大不同。 然而，迄今为止，灵长类动物中有关此主题的信息很少。结果表明，在啮齿动物脑干和脊髓中广泛存在的雌激素受体-α含有神经元的存在，相反，它们集中在参与副感觉，听觉和自主处理的恒河猴的区域。雌激素处理没有导致雌激素受体免疫反应神经元的分布模式的显着差异。因此，通过雌激素受体-α的雌激素作用在灵长类动物的脑干和脊髓系统的功能中起着适度的作用。此外，在灵长类动物和小鼠脑干和脊髓中ER-_ IR神经元的分布存在质和量的差异，这表明在灵长类动物中ER-_IR在雌激素介导的行为控制中起的作用比啮齿类动物小。这项研究使用WNPRC动物服务。 这项工作得到了RR 00167（1997-1998）补充资金的支持，在本报告所述期间出版了一份出版物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the distribution pattern of estrogen receptor-alpha in the brainstem and spinal cord of ovariectomized female monkeys to understand the role of estrogen in women's health. Because estrogen dependency in sexual behaviors differs in primates and rodents, the distribution pattern of estrogen receptors in the brainstem and spinal cord of primates would be quite different. However, to date there is little information on this topic in primates. The results suggest that in contrast to the presence of estrogen receptor-alpha containing neurons in a widespread area in the rodent brainstem and spinal cord, they are concentrated to regions involved in vicero-sensory, auditory, and autonomic processing in rhesus monkey. Estrogen treatment did not result in significant differences in the distribution pattern of estrogen receptor immunoreactive neurons. Therefore, estrogen action through estrogen receptor-alpha plays a modest role in function of the brainstem and spinal systems in primates. Moreover, there is qualitative and quantitative differences in the distribution of ER-_ IR neurons in the primates and mice brainstem and spinal cord, suggesting that in primates ER-_ plays a more modest role in control of estrogen-mediated behaviors as compared to rodents. This research used WNPRC Animal Services. This work was supported by supplemental funding to RR00167 (1997-1998) and a publication has resulted during this reporting period.