The VALIDATE study

这是一项纵向的观察性研究，不包括任何干预。有三个学习小组。第一组由无已知冠状动脉疾病的BLSA参与者组成；第二组由冠状动脉钙化评分低于其年龄和性别的第25百分位数的个人组成；第三组由患有早发性冠状动脉疾病的个人组成(女性在60岁时确诊，男性在50岁时确诊)或冠状动脉钙化评分大于他们的年龄和性别的第50百分位数。 上面列出的第二组和第三组的参与者是从约翰·霍普金斯医疗机构招募的。这些小组的招募工作已按计划进行或提前进行，我们已准备好开始研究的纵向部分。第一组的招募是在国家老龄研究所进行的。在过去的一年里，我们招募这些志愿者的能力有了明显的提高，我们希望继续这一趋势。为了达到我们的目标，我们设定了每月约10名BLSA参与者的目标。

This is a longitudinal, observational study, which does not include any intervention. There are three study groups. The first group consists of BLSA participants without known coronary disease; the second consists of individuals with a coronary artery calcium score less than the 25th percentile for their age and gender; the third group consists of individuals with premature coronary artery disease (diagnosis made at age <60 in females and <50 in males) or with a coronary calcium score which is greater than the 50th percentile for their age and gender. Participants in the second and third group listed above are recruited from the Johns Hopkins Medical Institutions. Recruitment into these groups has been on or ahead of schedule, and we are ready to begin the longitudinal component of the study. Recruitment into the first group is performed at the National Institute on Aging. The past year saw a marked improvement in our ability to recruit these volunteers, and we hope to continue this trend. To reach our goal, we have set a target of approximately 10 BLSA participants per month.