The Role of the Direct and Indirect Striatal Pathways in Movement and Learning

描述(申请人提供)：许多疾病，包括帕金森氏病、亨廷顿氏病和药物成瘾，都与被称为基底节的大脑系统功能障碍有关。尽管对这一系统进行了数十年的研究，但没有针对这些疾病的长期治疗或治愈方法。这项建议旨在使用新技术来研究基底节，从而确定治疗基底节疾病的新策略和新见解。 公共卫生相关性：许多疾病，包括帕金森氏病、亨廷顿氏病和药物成瘾，都与被称为基底节的大脑系统功能障碍有关。尽管对这一系统进行了数十年的研究，但没有针对这些疾病的长期治疗或治愈方法。这项建议旨在使用新技术来研究基底节，从而确定治疗基底节疾病的新策略和新见解。

DESCRIPTION (provided by applicant): Many diseases, including Parkinson's disease, Huntington's disease, and drug addiction, have been linked to dysfunction in a brain system called the basal ganglia. Despite decades of research on this system, there are no long-term treatments or cures for these disorders. This proposal aims to use novel techniques to investigate the basal ganglia, and thereby identify novel strategies and insights for treating diseases of the basal ganglia. PUBLIC HEALTH RELEVANCE: Many diseases, including Parkinson's disease, Huntington's disease, and drug addiction, have been linked to dysfunction in a brain system called the basal ganglia. Despite decades of research on this system, there are no long-term treatments or cures for these disorders. This proposal aims to use novel techniques to investigate the basal ganglia, and thereby identify novel strategies and insights for treating diseases of the basal ganglia.