Genomics and Transgenics

同源菌株的发展仍然是缩短间隔和证明突变存在的最有力的工具。对于项目1，我们将把间隔从13.2 Mb减少到<5Mb，对于项目3，我们将从2.5 Mb减少到< Mb，但仍然保留血管生成表型。除了项目1的基因鉴定外，我们还希望获取基因通路信息，我们将研究更大的区域；而。项目3只关注血管生成表型，需要更精细的分辨率。

Development of congenic strains remains the most powerful tool to reduce an interval and demonstrate the mutation is present. For Project 1, we will reduce the interval from 13.2 Mb to <5Mb, and for Project 3 from 2.5 Mb to < Mb, yet to still retain the angiogenic phenotype. As we are looking to capture gene pathway information in addition to gene identification for Project 1, we will study a larger region; whereas. Project 3 is solely focused on the angiogenesis phenotype requires the finer resolution.