Imaging, Probes and Biostatistics

成像和探测器资源将提供一种无缝转换的方法，该方法将集成多模式 MR、PET、SPECT以及光学成像和探针的开发，以了解和有效治疗 癌症。JHU ICMIC应用中的研究需要广泛的成像方法和 成像探针的开发跨越了对诸如1号胶原纤维等微观结构的成像，以 人类癌症移植和转基因模型的临床前成像，为癌症患者成像。这 资源将提供必要的基础设施，并作为JHU ICMIC调查人员的中央资源 获得多模式成像、图像可视化和分析方面的专业知识和帮助，以及 成像探头的开发。该资源还将进行成像和成像方面的研究和开发 JHU ICMIC中的探头发展。该资源将在识别和开发方面发挥宝贵的作用 随着单个研究项目在该计划中的发展，新的成像技术和探测器。这个 这一资源的目的是：(1)指导和协助调查人员使用成像技术，并 确定最适合研究的成像技术，(Ii)开发和提供最新的 多模式成像数据所需的最先进的图像分析和可视化，(Iii)识别， 开发和提供用于磁共振、放射性核素和光学成像应用的新型造影剂，(Iv) 针对中心研究计划过程中确定的关键目标开发代理， (V)确定最有前景的临床前成像技术和试剂，以供未来临床使用。成员 这种资源在成像和探头开发方面是通用的，并且可以在 产生共同努力的资源。

The Imaging and Probes Resource will provide a seamless translational approach that will integrate multimodality MR, PET, SPECT, and optical imaging and probe development to understand and effectively treat cancer. The research studies in this JHU ICMIC application require a wide range of imaging methods and imaging probe development that span the imaging of microscopic structures such as collagen 1 fibers, to preclinical imaging of human cancer xenografts and transgenic models, to imaging cancer patients. This resource will provide the requisite infrastructure and act as a central resource for JHU ICMIC investigators to obtain expertise and assistance for multi-modality imaging, image visualization and analyses, and imaging probe development. This resource will also perform research and development in imaging and probe development in the JHU ICMIC. The resource will play a valuable role in identifying and developing novel imaging technologies and probes as individual research projects evolve within the program. The aims of this resource are to: (i) Guide and assist investigators in the use of imaging technologies, and to identify the most appropriate imaging technology for the research studies, (ii) Develop and provide state-of- the-art image analyses and visualization necessary for multi-modality imaging data, (iii) Identify, develop, and provide novel contrast agents for MR, radionuclide, and optical imaging applications, (iv) Develop agents against critical targets identified during the course of the research programs in the center, (v) Identify the most promising preclinical Imaging techniques and agents for future clinical use. Members of this resource are versatile in imaging and probe development and can function interchangeably in this resource resulting in a commonality of effort.