Patient Oriented Research in Kidney Disease

简介(申请人提供)：徐志远，医学博士，硕士，正在申请以患者为中心的研究(K24)职业中期研究员奖，以加强他的原创研究和指导努力。这项由这笔赠款支持的新研究利用了许博士正在进行的资助项目，并代表了他先前工作的主题扩展。它还旨在为学员提供培训机会。其基本主题是在几个方面促进对急性肾功能恶化的意义和性质的理解。具体目标是：目标1：确定总体和临床重要亚组中急性肾功能衰竭(ARF)/急性肾损伤(AKI)的人群发病率，并确定其背后的潜在驱动力。目的2：确定肾功能突然丧失作为从慢性肾脏病(CKD)到终末期肾病(ESRD)的直接途径的重要性。目的3：确定急性心力衰竭时急性肾功能恶化的程度与肾小管损伤标志物水平升高的关系。许博士在加州大学旧金山分校有良好的导师经验，并在丰富、支持和合作的机构环境中工作。来自K24奖项的资金将使许博士在行政和临床责任上花费更少的时间，而在研究和指导上花费更多的时间。

DESCRIPTION (provided by applicant): Chi-yuan Hsu, MD, MSc is applying for a Mid-career Investigator Award in Patient Oriented Research (K24) in order to augment his original research and mentorship efforts. The new research to be supported by this grant leverages Dr. Hsu's ongoing funded projects and represents thematic expansions of his prior work. It is also designed to provide training opportunities for mentees. The underlying theme is to advance understanding of the significance and nature of acute deteriorations in kidney function on several fronts. The specific aims are: Aim 1: To determine the population incidence of acute renal failure (ARF)/acute kidney injury (AKI) overall and in clinically important subgroups and to determine potential driving forces behind this. Aim 2: To determine the importance of abrupt loss of renal function as a pathway leading directly from chronic kidney disease (CKD) to end-stage renal disease (ESRD). Aim 3: To determine the extent to which acute kidney function deterioration in the setting of acute heart failure is associated with elevated levels of markers of renal tubular injury. Dr. Hsu has a strong prior track record of mentorship and works within the rich, supportive and collegial institutional environment at UCSF. Funding from this K24 award will permit Dr. Hsu to spend less time on administrative and clinical responsibilities and more time on research and mentoring.