Developmental Activities

达特茅斯技术中心（DCCNE）内的发展活动将被设计为：(1)促进癌症纳米技术的研究；(2)促进癌症中心的肿瘤学家与塞耶工程学院的工程师和材料科学家的互动；(3)促进DCCNE研究人员提出研究建议，并就参与CCNE联盟的机构综合能力可行的项目进行合作；(4)联盟挑战项目。达特茅斯学院已经在癌症纳米技术方面进行了五年多的试点项目，最近一次是在2009年秋季资助了四个新项目，行政核心的工作人员有多年成功实施此类机制的经验。我们期待与联盟成员在与达特茅斯发起的项目相关的各种纳米技术合作方面进行丰富的双向互动，并有机会让感兴趣的DCCNE教师加入联盟研究。我们预计，其他研究中心在纳米技术平台合成方面的见解，以及与动物使用纳米结构相关的生物相容性问题，将为DCCNE提供新的机会。此外。基于联盟的抗体偶联和靶向配体纳米结构的经验可以为DCCNE提出的工作提供重要的研究协同效应。

Developmental activities arising within the Dartmouth CCNE (DCCNE) will be designed to (1) foster research in cancer nanotechnology; (2) facilitate interactions of oncologists at the Cancer Center with engineers and materials scientists at Thayer School of Engineering; (3) facilitate efforts by DCCNE investigators to propose studies and collaborate on projects that are made feasible by the composite capabilities of the institutions participating in The CCNE Alliance; and (4) Alliance Challenge Projects. Dartmouth has fostered pilot projects in cancer nanotechnology for more than five years, most recently funding four new projects in Fall 2009, and the staff members ofthe Administrative Core have many years experience implementing such mechanisms successfully. We anticipate rich bidirectional interactions with The Alliance members in collaborating on diverse nanotechnologies relevant to Dartmouth-initiated projects and the opportunity for interested DCCNE faculty to join in Alliance studies. We anticipate that insights from other centers in the synthesis of nanotechnology platforms, and in biocompatibility issues related to the use of nanostructures in animals will provide new opportunities for the DCCNE. In addition. Alliance-based experience in the conjugation of antibodies and targeting ligands to nanostructures can provide significant research synergies for work proposed by the DCCNE. The Dartmouth CCNE is also well positioned to collaborate productively with national resources such as the NCI Nanotechnology Characterization Laboratory and caNanoLab. The DCCNE recognizes the need for national collaborations on initiatives to advance the field of cancer nanotechnology, and the Center looks forward to contributing effort toward participating in Alliance initiatives to achieve this aim. The DCCNE Director will serve on the Alliance Coordinating and Governance Committee as representative of the Dartmouth CCNE and as a contributor to peer initiatives arising from that forum. His participation will represent the portal whereby additional DCCNE faculty can be identified as key resources for considerations on other issues of common interest across the Alliance, including such areas as clinical translation and industrial commercialization.