Improved outcomes for children with cancer through improved target identification and drug discovery: neuroblastoma as a model

大多数患有神经母细胞瘤的儿童仍然死于他们的疾病，幸存者有严重的癌症治疗副作用。我们的目标是为患有这种癌症的儿童发现更好的治疗方法，使用现有和新药物进行临床试验。我们还将研究靶向神经母细胞瘤细胞的新方法，并研究这种和其他胚胎性癌症的可能预防策略。这项工作将应用于其他儿童和成人癌症。

The majority of children with neuroblastoma still die of their disease, and survivors have serious side-effects of cancer treatment. We aim to discover better therapies for children with this cancer, conducting clinical trials using existing and new drugs in novel combinations. We will also investigate novel ways of targeting neuroblastoma cells, and study possible prevention strategies for this and other embryonal cancers. This work will have application in other childhood and adult cancers.