Improving the treatment for childhood cancer: Neuroblastoma as a model

改善儿童癌症的治疗：以神经母细胞瘤为模型

• 批准号: nhmrc : 401129
• 负责人: Prof Glenn Marshall
• 金额: $ 335.34万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Programs
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/improving-treatment-childhood-neuroblastoma-model/76518
• 关键词: Improving; treatment; childhood; cancer; Neuroblastoma

One in three children with cancer still die of their disease, and side-effects of treatment are considerable. Over the past 15 years, the Chief Investigators have established themselves as a leading international research group in child cancer and have successfully applied their laboratory-based discoveries to improve the clinical management of children with malignant diseases. In particular, key advances have been made in basic cell biology, molecular biology and in defining clinically relevant molecular targets and prognostic indicators for the child cancer, neuroblastoma, the commonest solid tumour in young children. These findings have been made possible by the team assembling, over recent years, an extensive and unique range of in vitro and in vivo model systems, together with a large bank of clinical neuroblastoma specimens. In this research program, the team members propose an experimental approach that will continue their studies, focussing on cancer initiation and better target identification within cancer cells, leading to the development of effective and non-toxic novel compounds, possibly prevention strategies,and introduction of novel therapies into clinical trial.

三分之一的癌症儿童仍然死于癌症，而且治疗的副作用相当大。在过去的 15 年里，首席研究员已将自己打造为儿童癌症领域领先的国际研究小组，并成功地将其基于实验室的发现应用于改善患有恶性疾病的儿童的临床管理。特别是，在基础细胞生物学、分子生物学以及定义儿童癌症、神经母细胞瘤（幼儿中最常见的实体瘤）的临床相关分子靶点和预后指标方面取得了关键进展。近年来，该团队组装了广泛且独特的体外和体内模型系统以及大量临床神经母细胞瘤标本，使这些发现成为可能。在该研究项目中，团队成员提出了一种实验方法，将继续他们的研究，重点关注癌症的发生和癌细胞内更好的靶点识别，从而开发出有效且无毒的新型化合物、可能的预防策略，并将新疗法引入临床试验。