Gynecologic Oncology Group Specimen Banking

描述（由申请人提供）：妇科肿瘤组（GOG）是一个主要的多学科，多模式临床试验研究项目，研究妇科恶性肿瘤管理的新治疗方法。GOG组织库，通过实验医学委员会组织利用小组委员会，是该计划的一个组成部分。自2003年以来，GOG组织库已收到并处理了来自250多个机构的近4.6万名患者的标本。世界银行还向215名调查人员分发了81 000多个标本，发表了122篇科学论文。这反映了研究人员通过NCI网站访问GOG组织库和通过合作人体组织网络建立研究人员网络的改善。GOG组织库监测和修改其组织采购和分发技术，以满足不断变化的研究者需求。在上一个拨款周期中，组织微阵列和虚拟显微镜技术的引入证明了这一点，我们的具体目标是；1. 扩大妇科肿瘤的分子研究范围，不仅包括卵巢癌，还包括子宫颈、子宫、原发性腹膜和罕见的妇科恶性肿瘤。2. 加强生物标本数据的收集，并与统计数据中心和所有参与GOG的学科和委员会进行交流，以推进转化研究和高影响力的发现。3. 通过扩大该技术的参与、使用和功能，扩展虚拟显微镜和妇科癌症数字病理学的范围。继续发展基于组织的技术，包括核酸提取和组织微阵列（TMAs），以促进分子研究。5. 通过NCI集团银行委员会的倡议，与其他合作集团银行协调，简化研究人员获取生物标本和相关数据的途径。

DESCRIPTION (provided by applicant): The Gynecologic Oncology Group (GOG) is a premier multidisciplinary, multimodal clinical trial research program investigating new therapeutic approaches in the management of gynecologic malignancies. The GOG Tissue Bank, through the Tissue Utilization Subcommittee of the Committee on Experimental Medicine, is an integral part of this program. Since 2003, the GOG Tissue Bank has received and processed specimens from close to 46,000 patients enrolled at over 250 institutions. The Bank also distributed over 81,000 specimens to 215 investigators, resulting in 122 scientific papers. This is reflective of improved access by investigators to the GOG Tissue Bank via NCI web sites and networking of investigators via the Cooperative Human Tissue Network. The GOG Tissue Bank monitors and modifies its tissue procurement and distribution technologies to meet changing investigator needs. This is evidenced by the introduction of tissue microarray and virtual microscopy technologies during the last grant cycle, Our Specific Aims are; 1. To extend the spectrum of molecular research in gynecologic cancer via expanded procurement of not only ovarian, but also cervical, uterine, primary peritoneal and rare gynecologic malignancies. 2. To enhance biospecimen data collection and exchange with the Statistical Data Center and all participating GOG disciplines and committees to advance translational research and high-impact discoveries. 3. To extend the spectrum of virtual microscopy and digital pathology for gynecologic cancer via expanded participation, use, and functionality of the technology 4. To continue to expand tissue-based technologies including nucleic acid extractions and tissue microarrays (TMAs) to facilitate molecular research. 5. To harmonize with other Cooperative Group Banks through NCI Group Banking Committee initiatives to simplify investigators' access to biospecimens and associated data.