ANIMAL CORE

我们的围绝经期脑老化和阿尔茨海默病计划项目（P3）的使命是 发现在围绝经期过渡期间大脑中发生的生物学变化， 在预测阿尔茨海默病发展风险的表型中。我们试图找出 这些变化发生的机制，并将这些发现转化为确定最佳时机 以及防止转化为围绝经期高危表型的策略。为了完成我们的使命， 我们将确定与不同周期过渡状态相关的围月经期表型; 参与这些表型发展的机制途径;并评估卵巢癌的影响。 激素和高脂饮食诱导肥胖（DIO）对阿尔茨海默病生物标志物表达影响。 动物中心（Core B）的使命是确保围绝经期项目的成功 通过提供项目1-3所需的动物。完成它的使命。动物核心将开发 围绝经期和绝经期的啮齿动物模型;从获得或出生开始维持和跟踪动物， 通过自行车状态的确定、研究入组、实验操作， 在整个围绝经期计划项目;并获得组织样本储存和遗传 分析核心分析 相关性（见说明）： 围绝经期过程的复杂性一直是基础和临床研究的主要障碍 of this aging老化transition过渡in women妇女.人类围绝经期啮齿动物模型的开发对于 提高对围绝经期对大脑影响的认识，识别有风险的表型， 年龄相关的神经系统疾病，并制定战略，促进健康的神经老化， 妇女预防老年痴呆症等与年龄有关的疾病。

The mission of our Perimenopause in Brain Aging and Alzheimer's Disease Program Project (P3) is to discover the biological changes that occur in the brain during the perimenopausal transition which can result in phenotypes predictive of risk for development of Alzheimer's pathology. We seek to identify the mechanisms by which these changes occur, and translate these discoveries to determine the optimal timing and strategies for preventing conversion to the perimenopausal at-risk phenotype. To achieve our mission, we will determine the perimenopausal phenotypes associated with different cycle transition states; delineate the mechanistic pathways involved in cJevelopment of these phenotypes; and assess the impact of ovarian hormone and high-fat diet induced obesity (DIO) on expression of Alzheimer's disease biomarkers. The mission of Animal Core (Core B) is to ensure the success ofthe Perimenopause Program Project through provision of animals as neecled to Projects 1-3. To achieve its mission. Animal Core will develop rodent models of perimenopause and menopause; maintain and track animals from acquisition or birth, though determination of cycling status, study enrollment, experimental manipulation, to fissue collection across the entire Perimenopause Program Project; and obtain tissue samples for storage and genetic analyses by Analytic Core. RELEVANCE (See Instructions): The complexity of the perimenopausal process has been a major barrier to both basic and clinical research of this aging transition in women. Development of rodent models ofthe human perimenopause is critical to advancing knowledge ofthe effects ofthe perimenopause on the brain, identifying phenotypes at risk for age-associated neurological diseases, and developing strategies that promote healthy neurological aging in women to prevent age-associated diseases such as Alzheimer's.