Biostatistics Core

为西雅图原发感染项目提供统计和数据库支持 对生物统计学和其他定量支持的需求是大多数医学研究的一部分，因此， SeaPIP项目将在某种程度上利用生物统计核心的资源，几乎在每一种类型的 进行的研究。最近在数据收集和测量工具方面取得的进展， 更复杂的数据类型，如病毒和细胞基因组学，病毒动力学和复杂的测量， 免疫反应：所有领域都将受益于与统计人员的投入和合作。通过包括MS级生物统计学家进行常规分析和博士级生物统计学家进行更高级分析的合作，SeaPIP生物统计学核心除了提供标准和必要的经典生物统计学支持外，还能够处理这些复杂的新问题。 此外，鉴于需要生物统计支持的项目多种多样，核心小组可提供 需要建立一个基础设施，将计划项目的不同统计和科学活动整合为一个整体，并确定项目间假设生成和探索性分析的机会。生物统计学核心将在所有三个项目中使用MS级SAS程序员和统计学家，这将为整个计划提供效率和经验广度。此外，Holte博士和Hughes博士将定期进行互动，讨论项目统计活动，以便每个项目都能从项目中所有三个项目的分析中获得的统计科学见解中受益。 最后，统计学家与临床和实验室研究人员之间最成功的合作是当同一研究人员长期合作时实现的。Holte博士拥有多年与SeaPIP研究人员合作的经验，因此她有能力继续支持这项科学计划的定量需求。

Statistical and database support for the Seattle Primary Infection Program The need for biostatistics and other quantitative support is part of most medical research and as such, the SeaPIP Projects will utilize the resources of the Biostatistics Core on some level in nearly every type of research conducted. Recent advances in data collection and measurement instruments result in more and more complex data types, such as viral and cellular genomics, viral dynamics, and sophisticated measures of immune responses: all areas that would benefit from input and collaboration with statisticians. By including MSlevel biostatisticians for routine analyses and PhD-level biostatisticians for collaboration on more advanced analyses, the SeaPIP Biostatistics Core is well equipped to handle these complex new problems, in addition to providing standard and necessary classical biostatistics support. In addition, given the diversity of projects requiring Biostatistical support, the Core can provide the infrastructure needed to integrate the disparate statistical and scientific activities of the Program Project as a whole, and identify opportunities for inter-project hypothesis generation and exploratory analyses. The Biostatistics Core will use MS-level SAS programmers and statisticians across all three projects which will provide efficiency and breadth of experience to the Program overall. Furthermore, Drs. Holte and Hughes will have regular interactions to discuss Program statistical activities so that each Project can benefit from statistical scientific insights gained in the analysis from all three Projects in the Program. Finally, the most successful collaborations between statisticians and clinical and laboratory researchers is achieved when the same researchers work together over long periods of time. Dr. Holte has many years of experience in collaborating with the SeaPIP investigators, so that she is well equipped to continue to support the quantitative needs of this scientific program.