Kentucky Center for Clinical and Translational Science

在英国肯塔基大学，我们建立了临床和翻译科学中心 (CCTS)作为临床和转化性研究的中心。英国位于列克星敦，位于 阿巴拉契亚中部，该国最贫穷的地区之一，那里的贫富差距前所未有 疾病和死亡率。这些差异中的许多都源于危险行为，如吸烟、吸毒、 还有肥胖症。在这项计划中，我们的总体目标是转变 英国的翻译研究将为阿巴拉契亚中部的人们带来更好的健康。科学 Discovery提供了改善护理的潜力，基于社区的研究提供了更快的影响 通过更好地传播最佳医疗保健来促进健康。然而，科学发现通常不会 由于导航复杂的临床和医疗流程存在许多困难，因此需要深入社区 翻译研究。在这项应用中，我们将充分利用我们在教育、基础和临床方面的优势 科学，以及我们在实践和基于社区的参与性研究方面的杰出计划。 这些努力将导致影响阿巴拉契亚农村社区健康的科学发现 短期内，并为未来的管道做好准备。为了实现这些目标，英国将成立一个 与距离西弗吉尼亚州亨廷顿2小时车程的马歇尔大学合作。此外，我们还将成立一个 阿巴拉契亚翻译研究网络不仅包括马歇尔，还包括俄亥俄州的CTSA 州立大学、辛西纳蒂大学、莫尔黑德大学和皮克维尔骨科学院 医学。这一网络将在我们强大的项目的进一步发展中发挥特别重要的作用 基于社区的参与性研究。为了帮助整合我们的努力，我们开发了一种创新的 一组教师催化剂，他们将在慷慨的飞行员的支持下建立协作团队科学项目 将针对科学各个层面的新想法的资金。CCTS在“药物开发”方面的新项目， “新方法论”和“风险相关行为研究”将利用我们的优势，参与 拥有不同专业领域的调查人员，并将更快地影响阿巴拉契亚地区的健康 社区。我们最近在生物医学信息学领域招聘了一位新的领导者，并在 这一计划将极大地提高我们在整个CCTS中将数据转化为知识的能力。 通过这些举措，英国将履行其作为肯塔基州旗舰大学的使命，以改善 阿巴拉契亚中部，从而为改善国家健康增加了独特的价值。

At the University of Kentucky (UK), we have established the Center for Clinical and Translational Science (CCTS) as a home for clinical and translational research. UK is located in Lexington, on the western edge of mid-Appalachia, one ofthe poorest areas ofthe country, where there are unprecedented disparities in disease and mortality. Many of these disparities stem from risky behaviors, such as smoking, drug abuse, and obesity. In this proposal, our overarching goal is to transform the pace, effectiveness, and quality of translational research at UK which will result in better health for the people of mid-Appalachia. Scientific discovery offers the potential for improved care, with community-based research offering a faster impact on health through a better dissemination of optimal medical care. However, scientific discoveries often do not reach the community due to the many difficulties with navigating the complex process of clinical and translational research. In this application, we will capitalize on our strengths in education, basic and clinical sciences, as well as our outstanding programs in practice- and community- based participatory research. These efforts will result in scientific discovery that will impact the health ofthe Appalachian rural community in the near term, and prime the pipeline for the future. To accomplish these goals, UK will form a collaboration with Marshall University, which is 2 hr away in Huntington, WV. In addition, we will form an Appalachian Translational Reseach Network involving not only Marshall, but also the CTSAs at the Ohio State University, University of Cinncinati, Morehead University, and Pikeville School of Osteopathic Medicine. This network will be especially important in the further development of our strong programs in community based participatory research. To help integrate our efforts, we have developed an innovative group of faculty CATalysts, who will build collaborative team science programs backed by generous pilot funding that will target novel ideas at all levels of science. New CCTS programs in "Drug Development", "Novel Methodologies", and "Risk-Related Behavior Research" will capitalize on our strengths, engage investigators with diverse areas of expertise, and will more quickly impact the health of the Appalachian community. We have recently recruited a new leader in Biomedical Informatics and have invested heavily in this program, which will greatly improve our ability to transform data into knowledge throughout the CCTS. Through these initiatives, UK will fulfill its mandate as Kentucky's flagship university to improve the health of Central Appalachia, and thereby add unique value to improvements in the health ofthe nation.