Los Angeles Basin Clinical and Translational Science Institute

这项修订后的临床和跨领域科学奖(CTSA)申请将支持受限制的 洛杉矶盆地临床和跨大西洋科学研究所(CTSI)的发展。我们的愿景是 改善洛杉矶城市多样化和服务不足人群的健康状况，并通过这样做，获得 我们可以与他人分享的知识，以改善城市环境和全球特大城市的健康状况 环球网。为了追求这一愿景，我们建立了独特的合作伙伴关系，包括领先的学术、临床和 洛杉矶市中心的社区卫生组织。我们正在将这种合作伙伴关系转变为 一家卓越的临床和转化科学研究所，专注于为多样化的城市提供更好的健康 社区。我们为CTSI确立了四个主要目标：建立在许多独立优势的基础上，以 创建一个高度重视临床和转化科学的综合学术之家； 新的翻译研究团队和实施项目，利用我们独特的人口和 合作伙伴关系，以解决我们当地最好的科学机会和最重要的健康优先事项 社区；改革教育和培训，培养一支以职业生涯为主要重点的干部队伍 临床和转化性研究；以及将我们所学到的改善健康的知识在我们的 并通过区域和国家网络促进翻译研究 合作。为了实现这些目标，我们组建了一支卓越的领导团队，正在创造 通过CTSI：积极开发新的研究项目和团队的杰出资源，AA 强大的基础设施，以促进和支持基础、临床和社区研究、前沿 数据采集、集成、管理和分析的方法论；基础、 临床和社区研究人员使用远程教育，专注于多样化的研究 社区；使用专业沟通传播我们的调查结果的新方法 专业知识；以及AA专业评估小组，跟踪和评估我们的进展和影响。使用330万美元 在制度的支持下，我们已经在将本地环境转变为 高度重视临床和跨性别研究的家园。我们展示了强大的生成和 支持令人兴奋的新研究，从替补席到我们的社区。通过CTSA和1870万美元的承诺 机构支持在五年内，我们将扩大到一个功能齐全的研究所，它将拥有一个主要的 对改善城市健康和推进临床和转化性研究学科的影响。

This revised application for a Clinical and Translafional Science Award (CTSA) would support the confinued development of the Los Angeles Basin Clinical and Translafional Science Institute (CTSI). Our vision is to improve health of the diverse and underserved populafion of urban Los Angeles and, in doing so, to gain knowledge that we can share with others to improve health in urban settings and megacities across the globe. In pursuit of that vision, we have established a unique partnership of leading academic, clinical and community health organizations in the urban heart of Los Angeles. We are transforming this partnership into a preeminent clinical and translational science institute focused on better heath for diverse, urban communities. We have established four main goals for the CTSI: abuild on many independent strengths to create an integrated academic home that places high priority on clinical and translational science; acreate new translational research teams and conduct projects that leverage our unique populations and partnerships to address the best scientific opportunities and most important health priorifies of our local communities; atransform education and training to create a cadre of people with a major career focus on clinical and translational research; and aimplement and disseminate what we learn to improve health in our local communities and advance translational research through regional and national networks and collaborations. To achieve these goals, we have assembled an exceptional leadership team that is creating through the CTSI: aoutstanding resources for active development of new research projects and teams, aa robust infrastructure to promote and support basic, clinical and community research, acutting edge methodologies for data acquisifion, integration, management and analysis; aintegrated training of basic, clinical and community researchers using distance education and a focus on research for the diverse communities; aa novel approach to dissemination of our findings using professional communications expertise; and aa professional evaluation group to track and evaluate our progress and impact. Using $3.3M of institutional support, we have already made significant progress in transforming our local environment to a home that highly values clinical and translafional research. We demonstrate strong ability to generate and support exciting new research, from the bench to our communities. With a CTSA and a pledge of $18.7M of institutional support over five years, we will expand to a fully functional institute that will have a have a major impact to improve urban health and advance the discipline of clinical and translational research.