Multidisciplinary Clinical and Translational Science (MCTS) Program (KL2)

为什么没有更多的人成功地将激动人心的科学发现转化为更好的病人 保健和社区保健（1，2）？可能的解释包括临床研究人员的短缺和高流动率 由于体制和环境支持不足（3）;不愿放弃传统的 以部门为中心的研究和培训模式;缺乏有效的教育博士科学家关于 人类健康和疾病的生理学和病理生理学（4）;以及在提供临床和实验室方面的差距 拥有在当前研究环境中取得成功所需工具的科学家，包括 跨学科团队在本节中，我们提出了这些可能的障碍的解决方案，并提供了一个 实施计划是可实现的，可以评估。¿ 我们的CTSA应用程序的这一关键组件的总体目标是创建下一代临床 代表多个学科的研究人员将成为边界专家，能够传播新的想法， 连接不同学科的实验室和研究人员。 西北大学几十年来一直致力于跨学科研究。它提供了激励措施 包括教师职位和研究资金，以打破学科之间的界限和障碍， 将生命科学和工程领域基于学科的研究生培训计划合并为4个综合项目， 跨校园地点的项目。我们建议在已经成功的计划的基础上再接再厉， 跨学科研究教育，培训和职业发展，建立临床中心， 研究教育（CCRE）。该中心将协调和加强现有的临床和翻译 研究教育，培训和职业发展活动;创建新的课程，研讨会和计划 并将其与现有活动相结合;通过包括博士预科课程来扩大我们课程的候选人库 培训学员和基础科学家;以不同于以往的方式， 扩大了一套课程和研讨会，并建立了跨学科，团队，并培养 培训人员使用精心挑选的导师和新的监督程序，包括标准化的跟踪工具。 该中心还将为临床研究和监管人员以及社区提供新的机会 investigators.该中心及其主要项目将由一个充满活力和经验丰富的领导团队领导。 具体目标是： 目标1：建立临床研究教育中心，使其成为临床和转化的家园 西北大学的研究教育，培训和职业发展; 目标2：提高目前的临床研究科学硕士（MSCI）和其他学位和证书 程序; 目标3：开发一个新的多学科临床和转化科学学者（K12）计划，重点是 博士后研究员和初级教员的需要; 目标4：开发一个新的博士前（T32）培训计划，以获得临床和翻译博士学位 科学或医学博士/博士与临床和转化科学博士学位; 目标5：为社区创建新的临床和转化研究教育和培训计划 临床研究者、护士、研究人员和住院医师; 目标6：扩大和加强导师发展的机会; 目标7：评估中心及其项目在创建下一代临床和 翻译研究者 在支持期结束时，CTSA将使NUCATS研究所能够开发出一个更加有效的 一套全面的培训计划，比目前可用的，以提供新的机会，在临床 为更广泛的学生，学员和教师进行翻译研究，并开始衡量 结果，并利用它们来产生变化。

Why have there.not been more successes in translating exciting scientific discoveries into improved patient care and community health (1,2)? Possible explanations include a shortage and high turnover rate of clinicianinvestigators due to insufficient institutional and environmental support (3); reluctance to let go of the traditional department-centric research and training models; a lack of effectiveness in educating PhD scientists about the physiology and pathophysiology of human health and disease (4); and a gap in providing clinical and bench scientists with the tools needed to be successful in the current research environment, including working in interdisciplinary teams. In this section we propose solutions to these possible barriers and provide an implementation plan that is achievable and can be evaluated. ¿ The overall goal of this key component of our CTSA application is to create the next generation of clinical researchers representing multiple disciplines who will be boundary spanners, able to pollinate new ideas and link laboratories and investigators in different disciplines. Northwestern University has fostered interdisciplinary research for several decades. It has provided incentives Including faculty positions and research funding to break the lines and barriers separating disciplines, and merged discipline-based graduate training programs in the life sciences and engineering into 4 integrated programs that span campus locations. We propose building on an already successful program of interdisciplinary research education, training and career development by establishing the Center for Clinical Research Education (CCRE). The Center will coordinate and enhance existing clinical and translational research education, training and career development activities; create new courses, seminars and programs and integrate them with existing activities; expand the candidate pool for our programs by including predoctoral trainees and basic scientists; educate/train the candidates differently than in the past using an expanded set of course offerings and seminars and established interdisciplinary, teams, and nurture the trainees using carefully chosen mentors and new oversight procedures including standardized tracking tools. The Center will also provide new opportunities for clinical research and regulatory staff and community investigators. The Center and its key programs will be led by a dynamic and experienced leadership team. The specific aims are to: Aim 1: Establish the Center for Clinical Research Education, and make it the home for clinical and translational research education, training and career development at Northwestern; Aim 2: Enhance the current Master of Science in Clinical Investigation (MSCI) and other degree and certificate programs; Aim 3: Develop a new Multidisciplinary Clinical and Translational Science Scholars (K12) Program focusing on the needs of postdoctoral fellows and junior faculty members; Aim 4: Develop a new predoctoral (T32) training program leading to a PhD in Clinical and Translational Science or MD/PhD with the PhD in Clinical and Translational Science; Aim 5: Create new clinical and translational research education and training programs for community-based clinical investigators, nurses, research staff and medical residents; Aim 6: Expand and enhance opportunities for the development of mentors; Aim 7: Evaluate the performance of the Center and its programs in creating the next generation of clinical and translational investigators. At the end of the period of support, the CTSA will have enabled the NUCATS Institute to develop a more comprehensive set of training programs than are currently available, to provide new opportunities in clinical and translational research for a broader range of students, trainees and faculty, and to begin to measure the results and use them to produce change.